The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study

Age
Catharina M C MelsAletta E Schutte

Abstract

Inadequate substrate availability and increased nitric oxide synthase inhibitor levels attenuate nitric oxide (NO) synthesis, whereas increased vascular oxidative stress may lead to inactivation of NO. We compared markers of NO synthesis capacity and oxidative stress in a bi-ethnic male population. Inter-relationships of ambulatory blood pressure and urinary albumin-to-creatinine ratio with NO synthesis capacity and oxidative stress markers were investigated. NO synthesis capacity markers (L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA)) and oxidative stress markers (serum peroxides, total glutathione, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase) were measured. Black men displayed higher blood pressure and albumin-to-creatinine ratio (all p < 0.001), while NO synthesis capacity was more favorable (higher L-arginine and lower ADMA (p ≤ 0.003)). Antioxidant enzyme activities were similar except for the redox status markers (GR activity and GR/GPx ratio), which were upregulated in black men (p < 0.001). In black men, ADMA was inversely related to GPx activity (R (2) = 0.15; β = -0.20; p = 0.050) and GPx/SOD ratio (R (2) = 0.24; β = -0.37; ...Continue Reading

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Citations

Sep 30, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Christine Susara du PlooyRuan Kruger
May 13, 2017·Cell Death and Differentiation·Debasis NayakAnindya Goswami
Jul 19, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ashleigh CraigRuan Kruger
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Apr 20, 2018·Oxidative Medicine and Cellular Longevity·Lei GaoChristopher W K Lai
Dec 7, 2019·Journal of Clinical Medicine·Iván Cavero-RedondoLuis García-Ortiz

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