The relationship of physicochemical properties to the antioxidative activity of free amino acids in Fenton system

Environmental Science & Technology
Sonja MilićIvan Spasojević

Abstract

Herein we compared antioxidative activities (AA) of 25 free L-amino acids (FAA) against Fenton system-mediated hydroxyl radical (HO(•)) production in aqueous solution, and examined the relation between AA and a set of physicochemical properties. The rank order according to AA was: Trp > norleucine > Phe, Leu > Ile > His >3,4-dihydroxyphenylalanine, Arg > Val > Lys, Tyr, Pro > hydroxyproline > α-aminobutyric acid > Gln, Thr, Ser > Glu, Ala, Gly, Asn, Asp. Sulfur-containing FAA generated different secondary reactive products, which were discriminated by the means of electron paramagnetic resonance spin-trapping spectroscopy. AA showed a general positive correlation with hydrophobicity. However, when taken separately, uncharged FAA exhibited strong positive correlation of AA with hydrophobicity whereas charged FAA showed negative or no significant correlation depending on the scale applied. A general strong negative correlation was found between AA and polarity. Steric parameters and hydration numbers correlated positively with AA of nonpolar side-chain FAA. In addition, a decrease of temperature which promotes hydrophobic hydration resulted in increased AA. This implies that HO(•)-provoked oxidation of FAA is strongly affected by...Continue Reading

References

May 1, 1991·International Journal of Peptide and Protein Research·S HellbergP Andrews
Oct 1, 1988·International Journal of Peptide and Protein Research·J L FauchèreV Pliska
Jan 1, 1984·Annual Review of Biophysics and Bioengineering·A A Zamyatnin
Dec 27, 2005·The Journal of Physical Chemistry. B·Peter VassilevEvert Jan Baerends
Jul 22, 2006·Environmental Science & Technology·Christopher K Duesterberg, T David Waite
Jul 14, 2007·The Journal of Physical Chemistry. a·Martine N BlomJos Oomens
Aug 23, 2007·Environmental Science & Technology·Hongwei JiJincai Zhao
Sep 15, 2009·Environmental Science & Technology·Daisuke MinakataJohn Crittenden
Nov 21, 2009·Environmental Science & Technology·Stuart W KrasnerGary Amy
Jul 6, 2010·Journal of the Science of Food and Agriculture·Dandan GaoHaixing Li
Aug 31, 2011·Critical Reviews in Clinical Laboratory Sciences·Ivan Spasojević
Sep 29, 2011·Journal of the American Chemical Society·Robert J O'ReillyLeo Radom
Dec 14, 2011·Chemical Reviews·Andrzej Burakowski, Jacek Gliński
Nov 23, 2012·Nature·Joel G DavisDor Ben-Amotz
Jan 25, 2013·Water Environment Research : a Research Publication of the Water Environment Federation·Evans M Nkhalambayausi-Chirwa, Moses T Lebitso

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Citations

Oct 6, 2015·Nitric Oxide : Biology and Chemistry·Bojana BolićIvan Spasojević
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Kimberly B BjugstadDavid Bar-Or
Sep 25, 2017·Antioxidants & Redox Signaling·Zhenlong WuGuoyao Wu
Aug 10, 2017·Journal of Paediatrics and Child Health·Simeon MinićMiroslav M Vrvić
Dec 12, 2018·Mass Spectrometry·Shinichi Enami, Agustín J Colussi
Aug 4, 2021·Amino Acids·Shengdi HuGuoyao Wu

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