The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia.

Malaria Journal
Jean-Pierre Van GeertruydenStephen Rogerson

Abstract

HIV-1 infection affects malaria humeral immunity during pregnancy, but data for non-pregnant adults are lacking. This study reports the impact of HIV-1 infection and other variables on the level of malaria humeral immunity in adults with clinical malaria and whether humeral immune suppression was a risk factor for treatment failure. Sera of 224 HIV-1 infected and 115 uninfected adults were compared for IgG to merozoite antigens AMA-1 and MSP2 (3D7 and FC27 types) determined by ELISA, and for IgG to the Variant Surface Antigens (VSA) of three different parasite line E8B, A4 and HCD6 determined by flow cytometry. Compared to HIV-1 uninfected adults, AMA-1 IgG was lower in HIV-1 infected (P = 0.02) and associated with low CD4 count AMA-1 IgG (P = 0.003). Low IgG to all three merozoite antigens was associated with less anemia (P = 0.03). High parasite load was associated with low MSP2 IgG 3D7 and FC27 types (P = 0.02 and P = 0.08). Antibody levels to VSA did not differ between HIV-1 infected and uninfected adults. However, low VSA IgGs were associated with high parasite load (P <or= 0.002 for each parasite line) and with treatment failure (P <or= 0.04 for each parasite line). HIV-1 affects humeral responses to AMA-1, but seems to m...Continue Reading

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Citations

May 6, 2014·The Journal of Infectious Diseases·Wina HasangStephen Rogerson
Feb 22, 2012·Expert Review of Anti-infective Therapy·Raquel GonzálezAlfredo Mayor
Apr 9, 2016·Medicine·Cho NaingVictor Nyunt Wai
Feb 18, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-P Van Geertruyden
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ricardo AtaideFreya J I Fowkes
Apr 22, 2017·Malaria Journal·Katherine O'FlahertyFreya J I Fowkes

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Methods Mentioned

BETA
ELISA
PCR
genotyping

Software Mentioned

STATA
info
Cell Quest
Epi

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