The Relationship of Retinal Vessel Geometric Characteristics to the Incidence and Progression of Diabetic Retinopathy

Ophthalmology
Ronald KleinBarbara E K Klein

Abstract

To examine the relationships of retinal vessel geometric characteristics (RVGCs) to the incidence and progression of diabetic retinopathy (DR). Observational, prospective cohort study. Nine hundred ninety-six persons with type 1 diabetes mellitus (T1DM) and 1370 persons with type 2 diabetes mellitus (T2DM) seen at a baseline examination who were eligible for follow-up examinations at subsequent 5-year intervals. A total of 3846 person-interval data from these follow-up examinations are the basis for the analyses. Diabetic retinopathy and macular edema were assessed by grading of 30° stereoscopic color fundus photographs. Retinal vessel geometric characteristics were assessed using the Singapore I Vessel Assessment program from a digitized copy of 1 of the field 1 fundus photographs obtained at baseline and follow-up. The 5-year incidence of any DR, progression of DR, and incidence of proliferative diabetic retinopathy (PDR) and clinically significant macular edema (CSME) in right eyes. Incident DR occurred in 45%, progression in 32%, PDR in 10%, and CSME in 5%. While adjusting for glycated hemoglobin, duration of diabetes, and other factors, retinal arteriolar simple tortuosity was associated significantly with the incidence of...Continue Reading

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Citations

Sep 27, 2020·Clinical Physiology and Functional Imaging·Holger SchirutschkeJens Passauer
Nov 16, 2020·Journal of Diabetes Investigation·Nicola QuinnLaima Brazionis
Jan 31, 2021·Diabetologia·Rachel B ForsterUNKNOWN Edinburgh Type 2 Diabetes Study (ET2DS) investigators
May 19, 2021·Translational Vision Science & Technology·Xinyu ZhaoYouxin Chen
Jun 11, 2021·Translational Vision Science & Technology·Selin L AuvazianMahnaz Shahidi

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