The relationship of serum total sialic acid with serum acute phase proteins and lipoprotein (a) in patients with severe hypertriglyceridaemia

European Journal of Clinical Investigation
M A CrookP Tutt

Abstract

Total serum sialic acid (TSA), recently shown to be a cardiovascular risk factor, was measured in 15 patients with severe hypertriglyceridaemia (fasting triglyceride > 2.3 mmol l-1) and 15 age and sex matched normal control subjects. To test the hypothesis that serum TSA is related in some way to serum acute phase proteins we also measured five acute phase proteins, namely alpha-1-antichymotrypsin (ACT), alpha-1-acid-glycoprotein (AGP), alpha-2-macroglobulin (AMG), C-reactive protein (CRP) and haptoglobin (HAP) in both groups. Of note was the significantly elevated serum TSA in the severely hypertriglyceridaemic group as compared to normal subjects. Serum TSA being 71.9 +/- 11.7 mg dl-1 and 59.6 +/- 10.2 mg dl-1 respectively (P < 0.01 Mann-Whitney test). Serum CRP was significantly elevated in the type IV patients as compared to controls (6.4 +/- 4.5 mg l-1 vs. 3.3 +/- 1.9 mg l-1 P < 0.05 Mann Whitney test) as was serum AMG (2.1 +/- 0.89 g l-1 vs. 1.5 +/- 0.53 g l-1 P < 0.05 Mann Whitney test). There was no correlation between serum TSA and lipoprotein (a) in either the normal or severely hypertriglyceridaemic subjects. We suggest that serum TSA could in part be related to hypertriglyceridaemia and serum acute phase proteins bu...Continue Reading

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Citations

Feb 12, 2000·Diabetes Research and Clinical Practice·M CrookA Worsley
Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mustafa CemekFatma Yilmaz
Jan 1, 1997·Metabolism: Clinical and Experimental·L MazzantiG Curatola
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M Crook
May 17, 2019·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Luis Manuel Sanchez

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