The relationship of soluble adhesion molecule concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury

Anesthesia and Analgesia
E G McKeatingL Mascia

Abstract

Adhesion molecules control the migration of leukocytes into tissue after injury. This may result in further cellular damage. We hypothesized that altered serum concentrations of soluble intercellular adhesion molecule (sICAM)-1 and soluble L-selectin (sL-selectin) after traumatic brain injury would correlate with injury severity and neurological outcome. We investigated serum concentrations of sICAM-1 and sL-selectin in 22 patients with traumatic brain injury admitted to the intensive care unit. The Glasgow Coma Scale (GCS) score and Injury Severity Score were recorded. Paired arterial and jugular venous blood samples were taken on admission and 24, 48, and 96 h after injury. Mean systemic and jugular venous concentrations of sICAM-1 were normal on admission but became significantly increased by 96 h (P = 0.018). sL-selectin concentrations of injured patients were markedly below those of controls at all time points (P < 0.001). There were no significant differences between jugular venous and arterial concentrations of either sICAM-1 or sL-selectin. Serum sICAM-1 was significantly related to neurological outcome (P < 0.001) and to the GCS score (P < 0.001). These changes in adhesion molecule expression after acute brain injury m...Continue Reading

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Citations

Dec 5, 2006·Intensive Care Medicine·Stefanos KorfiasDamianos E Sakas
Mar 26, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji-Hong XuYi-Nan Zhang
May 25, 2007·Neurocritical Care·Stephen M BloomfieldJonathan Brisman
Oct 9, 2009·Journal of Neurotrauma·Robert SimanM Sean Grady
Feb 3, 2012·Translational Stroke Research·Adam ChodobskiJoanna Szmydynger-Chodobska
Jun 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhexuan LinWenhong Luo
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Nov 6, 2013·Immunotherapy·Stefano Angiari, Gabriela Constantin

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