The relationship of testosterone to prostate-specific antigen in men with sexual dysfunction

The Journal of Sexual Medicine
Giovanni CoronaMario Maggi

Abstract

Concern about a testosterone (T)-induced prostate-specific antigen (PSA) increase is often perceived as one of the main limitations in treating hypogonadism even when it is symptomatic, such as in subjects with sexual dysfunction (SD). The aim of this study was to evaluate the relationship between T and PSA levels in subjects with SD. Methods. We retrospectively evaluated the relationship between T and PSA in 2,291 subjects seeking medical care at our outpatient clinic for SD (sample A). The analysis was then repeated in a selected subpopulation of 1,421 subjects apparently free from prostatic diseases (sample B). The specific association between PSA levels, circulating androgens, and different clinical signs and symptoms of hypogonadism, as assessed by ANDROTEST structured interview, was evaluated. In both samples A and B, subjects with higher PSA levels reported a lower prevalence of hypogonadism-related symptoms and signs, as well as higher total testosterone (TT), and analogue and calculated free T. However, when the association between PSA and T was evaluated as a function of T deciles, the upper nine groups had similar PSA values, with the lowest demonstrated a significantly reduced PSA (the lowest vs. the rest of the sam...Continue Reading

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Citations

Sep 24, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·G CoronaM Maggi
Feb 8, 2011·Journal of Endocrinological Investigation·G CoronaM Maggi
Jan 18, 2012·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
Apr 5, 2011·The Journal of Sexual Medicine·Emmanuele A JanniniWayne J G Hellstrom
Jun 8, 2012·The Journal of Sexual Medicine·Mark R Feneley, Malcolm Carruthers
Jun 30, 2011·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
Jul 19, 2013·The Journal of Sexual Medicine·Giulia RastrelliMario Maggi
Aug 1, 2014·Expert Opinion on Pharmacotherapy·Giovanni CoronaMario Maggi
Sep 18, 2013·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Feb 15, 2020·Andrology·Eduardo P Miranda, Luiz Otávio Torres
May 13, 2017·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Dec 5, 2020·Pakistan Journal of Biological Sciences : PJBS·Ayman A M AlameenMuhammad Atif
Jan 7, 2021·International Journal of Cancer. Journal International Du Cancer·Maria J Monroy-IglesiasKerri Beckmann
Feb 16, 2021·Archives of Endocrinology and Metabolism·Collins AmadiEhimen P Odum

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