The relationships between adverse events, early antecedents, and carbon dioxide reactivity as an intermediate phenotype of panic disorder: a general population study

Psychotherapy and Psychosomatics
Anna OgliariMarco Battaglia

Abstract

Although adverse events have been consistently described to precede and potentially precipitate the onset of panic disorder, there is no information about their ability to alter the individual reactivity to inhaled carbon dioxide, a putative intermediate phenotype of susceptibility to panic disorder. Seven-hundred twelve subjects belonging to the general population-based Norwegian Institute of Public Health Twin Panel underwent a 35% CO(2)/65% O(2) inhalation challenge test and interview-based lifetime assessments of DSM-IV panic disorder, separation anxiety disorder, childhood parental separation/loss, major life events, adverse events of suffocative nature and common stressful life events. Regression models were applied to predict global subjective anxiety and DSM-IV panic symptoms after 35% CO(2)/65% O(2) inhalation. The responses to the challenge measured as semicontinuous variables were predicted by symptoms of childhood separation anxiety, childhood parental loss, common stressful events, major life events, suffocative events and the female gender. The role of most of these predictors was confirmed and held true after the exclusion of subjects with lifetime panic attacks/disorder from the analyses. Several factors which h...Continue Reading

Citations

Feb 11, 2012·Clinical Psychology Review·Kristin VickersAndrea Woznica
Apr 24, 2013·International Archives of Occupational and Environmental Health·Christian MonséJürgen Bünger
May 1, 2012·Journal of Affective Disorders·Ozgür AtlıTunç Alkın
Mar 24, 2010·Journal of Anxiety Disorders·J Anthony RicheyKiara R Timpano
Jul 5, 2015·Psychiatry Research·Andrea WoznicaKatie Fracalanza
Oct 22, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Julio Mario Xerfan do AmaralAntonio Egidio Nardi
Dec 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chiara A M SpatolaMarco Battaglia
Feb 28, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marco Battaglia
Jan 26, 2013·Depression and Anxiety·Roxann Roberson-NayMarco Battaglia
Feb 13, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Miriam A SchieleKatharina Domschke

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