PMID: 1196303Nov 14, 1975Paper

The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism

Molecular and Cellular Biochemistry
Y S ShinE L Stokstad

Abstract

The relationship between vitamin B12 and folate and the effect of methionine on folate metabolism during B12 deficiency in rats is best explained by the prevention of the accumulation of 5-methyl-H4PteGlu by vitamin B12 and/or methionine. Although several points remain to be clarified, the 'methyl trap' hypothesis provides the most satisfactory explanation for the relation between vitamin B12, methionine and folic acid. This concept is extended by the hypothesis that H4PteGlu is the most active substrate for pteroylpolyglutamate synthetase, and thus accounts for the effect of methionine or vitamin B12 increasing liver folate levels.

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Citations

Mar 1, 1990·British Journal of Haematology·R DeaconI Chanarin
Apr 1, 1992·Journal of Clinical Pathology·I ChanarinJ Perry
Oct 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·B BarbiroliM Marchetti
Mar 1, 1985·European Journal of Pediatrics·L CorbeelR Eeckels
Feb 1, 1994·Mayo Clinic Proceedings·A Tefferi, R K Pruthi
Dec 22, 1999·The Proceedings of the Nutrition Society·M Chopra, D I Thurnham
Nov 1, 1983·Scandinavian Journal of Haematology·N A Sourial, L Brown
May 23, 2001·Experimental Biology and Medicine·N M van der PutH J Blom

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