The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi

Parasite Immunology
S Kumar, R L Tarleton

Abstract

The life cycle of the protozoan parasite Trypanosoma cruzi in mammalian hosts includes both non-dividing trypomastigote forms which circulate in the blood and replicating intracellular amastigotes which reside within the cytoplasm of a variety of host cells. In this study we have used mice with induced mutations in genes responsible for either antibody production or cytolytic T lymphocyte (CTL) function to examine the relative contributions of these effector mechanisms to control of T. cruzi. Mice deficient in the production of antibodies exhibited a delay in the rise in acute phase parasitaemia and an extended time to death relative to mice lacking CD8+ T cells. Nevertheless, B cell deficient mice eventually succumbed to the infection. Prior infection with an avirulent strain of T. cruzi failed to protect either CD8+ T cell-deficient mice or B cell deficient mice from challenge infection with virulent parasites. In contrast, mice with disruptions in the genes controlling perforin- or granzyme B-mediated cytolytic pathways had parasitaemia and mortality rates similar to wild-type mice and were protected from secondary infection by prior exposure to avirulent parasites. These results 1) confirm that antibody production, although...Continue Reading

References

Nov 1, 1991·European Journal of Immunology·O RötzschkeH G Rammensee
Feb 1, 1992·Experimental Parasitology·S SpinellaM Hontebeyrie-Joskowicz
Dec 1, 1989·Immunology and Cell Biology·C I BrodskynI Mota
Feb 1, 1988·Experimental Parasitology·M E RottenbergE L Segura
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M T RimoldiK Joiner
Dec 1, 1981·The Journal of Experimental Medicine·I K De Miranda-Santos, A Campos-Neto
Jan 1, 1995·International Reviews of Immunology·W R ClarkM Matloubian
Nov 17, 1995·Science·T S GriffithT A Ferguson
Apr 7, 1995·Cell·G Berke
Feb 1, 1995·Scandinavian Journal of Immunology·M E RottenbergA Orn
Jan 1, 1996·Infection and Immunity·E C Santos Lima, P Minoprio
Aug 1, 1996·Current Opinion in Immunology·L G Guidotti, F V Chisari
Jan 1, 1995·Critical Reviews in Immunology·E A Atkinson, R C Bleackley
Nov 1, 1996·Experimental Parasitology·I A Abrahamsohn, R L Coffman
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·K B ElkonE Falck-Pedersen

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Citations

Aug 27, 1999·Immunology Today·S StengerR L Modlin
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Thomas JacobsMatthias Leippe
May 23, 2006·Infection and Immunity·José L ReyesMiriam Rodríguez-Sosa
Mar 20, 2001·Infection and Immunity·M SaeftelA Hoerauf
Jun 24, 2004·Infection and Immunity·Kara L Cummings, Rick L Tarleton
Jun 3, 2000·Annual Review of Immunology·J T HartyD W White
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Feb 9, 2012·Journal of Parasitology Research·María C Amezcua VeselyAdriana Gruppi
Apr 13, 2012·Journal of Parasitology Research·Mauricio M RodriguesMaria Bellio
Mar 19, 2013·Veterinary Research·Minerva Arce-FonsecaOlivia Rodríguez-Morales
Jun 27, 2002·International Journal of Experimental Pathology·Andrea Henriques-PonsTania C Araujo-Jorge
Apr 3, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Orlando A TorresJavier Martín
Feb 16, 2010·Current Opinion in Immunology·Romina S Goldszmid, Alan Sher
Sep 30, 2009·Experimental Parasitology·Leony Cristina CaetanoAna Amélia Carraro Abrahão
Aug 25, 2009·Experimental Parasitology·Ana Claudia Henriques PintoJosé Clóvis do Prado
Sep 14, 2004·Immunological Reviews·Diana Martin, Rick Tarleton
Apr 1, 2008·Journal of Pineal Research·Fabricia Helena SantelloJosé Clóvis do Prado
Mar 29, 2014·Proteomics. Clinical Applications·Lars T Joeckel, Phillip I Bird
Jan 15, 2010·Journal of Cellular and Molecular Medicine·Silvia Beatriz BoscardinAriel Mariano Silber

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