The relative efficacy of fluoride toothpastes assessed with pH cycling

Caries Research
J M ten CateM J Buijs

Abstract

This study addressed the dose response between fluoride toothpastes and in vitro de- and remineralization, to predict the efficacy of toothpastes and understand the mode of action in the range 0-3,000 ppm F. Enamel lesions were pH-cycled with calcium uptake and loss being assessed daily. Both 'shallow' (about 50 microm deep) and 'deep' (about 200 microm deep) lesions were studied. F treatments were given in 30 (w/v)% toothpaste dilutions for up to 5 min daily. Calcium loss during the demineralization periods showed a dose response, resulting in 72% reduction for 3,000 ppm F compared to 0 ppm F. Calcium uptake during remineralization was increased in the F compared to non-F groups, with F concentration being less important than its mere presence. Significant differences were observed in F response between shallow and deep lesions, suggesting that this parameter should be included when testing caries-preventive products. Microradiographic analysis showed that lesion depth and severity had increased significantly in the non-F groups. In the F groups, the original lesion was partly remineralized, while a new lesion had formed beyond the original lesion front. Mineral loss of this second lesion correlated inversely with the F concen...Continue Reading

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Citations

Jan 27, 2012·Clinical Oral Investigations·Younju KimJuhea Chang
Apr 7, 2010·Journal of Materials Science. Materials in Medicine·Robert L KarlinseyKatherine E Frederick
Dec 25, 2007·Clinical Oral Investigations·Tsutomu TakatsukaJacob M ten Cate
Jun 9, 2012·Journal of Dentistry·E A NaumovaW H Arnold
Sep 11, 2008·Australian Dental Journal·J M ten Cate
Sep 14, 2007·International Dental Journal·R RanaN M King
Mar 20, 2016·Clinical Oral Investigations·M Esteves-OliveiraJ A Rodrigues
Jan 10, 2014·International Dental Journal·David Churchley, Bruce R Schemehorn
Mar 5, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Hussam MillyAvijit Banerjee
Apr 21, 2011·Journal of Dentistry·Peter TschoppeAndrej M Kielbassa
May 1, 2016·Pathogens and Disease·Hubertine Marjoleine WillemsBastiaan P Krom
Sep 24, 2008·Journal of Dental Research·J M ten CateR A M Exterkate
Jan 13, 2015·Journal of Dental Research·M ZhangD M Deng
Dec 19, 2007·Caries Research·A LussiT Jaeggi
Jan 19, 2018·Clinical Oral Investigations·R J WierichsM Esteves-Oliveira
Dec 18, 2018·Journal of Investigative and Clinical Dentistry·Jing-Yuan PengMichael G Botelho
Apr 22, 2017·International Journal of Dentistry·Frank Lippert
Oct 12, 2018·Clinical Oral Investigations·Carolin WaltherRichard Johannes Wierichs
Sep 14, 2010·Journal of Applied Oral Science : Revista FOB·Marília Afonso Rabelo BuzalafAlberto Carlos Botazzo Delbem
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Jan 10, 2014·International Dental Journal·Alex G StovellRichard J M Lynch
Feb 27, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·N A Al-EesaS Shahid
Nov 28, 2019·Caries Research·Richard J WierichsMarcella Esteves-Oliveira

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