The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: a network meta-analysis of randomised controlled trials

Osteoarthritis and Cartilage
Monica S M PerssonWeiya Zhang

Abstract

To compare the efficacy of topical non-steroidal anti-inflammatory drugs (NSAIDs) with topical capsaicin for pain relief in osteoarthritis (OA). A systematic literature search was conducted for randomised controlled trials (RCTs) examining any topical NSAID or capsaicin in OA. Pain relief at or nearest to 4 weeks was pooled using a random-effects network meta-analysis (NMA) in a Frequentist and Bayesian setting. Analysis was conducted for all trials and for trials using drugs listed as licensed for OA in the British National Formulary (BNF). The trial network comprised 28 RCTs (7372 participants), of which 17 RCTs (3174 participants) were included in the as licensed analyses. No RCTs directly compared topical NSAIDs with capsaicin. Placebo was the only common comparator for topical NSAIDs and capsaicin. Frequentist and Bayesian effect size (ES) estimates were in agreement. Topical NSAIDs were statistically superior to placebo overall (ES 0.30, 95% confidence interval [CI] 0.19 to 0.41) and as licensed (ES 0.32, 95% CI 0.24 to 0.39). However, capsaicin was only statistically superior to placebo when used at licensed doses (ES 0.41, 95% CI 0.17 to 0.64). No significant differences were observed in pain relief between topical NSAI...Continue Reading

Citations

Sep 12, 2020·Journal of Orthopaedic Surgery and Research·Jia Zhu TangBo Wang
Aug 23, 2019·Molecular and Cellular Biochemistry·Jian CaoJinlong Li
Jul 2, 2020·Wiener klinische Wochenschrift·Nicola VeroneseLeonardo Punzi
Sep 3, 2020·Pharmaceuticals·Stanislav SukhikhSvetlana Ivanova
May 10, 2019·Nature Reviews. Rheumatology·Philip G ConaghanPaul P Tak
Jul 28, 2020·International Journal of Molecular Sciences·Gaber El-Saber BatihaHelal F Hetta
Oct 31, 2020·Pain Management·Marina Fayet, Martina Hagen
Dec 19, 2020·Minerva anestesiologica·Gabriele FincoSalvatore Sardo
Feb 4, 2021·Current Pain and Headache Reports·Jillian MaloneyNatalie Strand
Jun 29, 2021·Current Treatment Options in Rheumatology·Alia M ObeidatRachel E Miller
Jul 25, 2021·Food & Function·Sahdeo PrasadSubash C Gupta
Jan 20, 2022·Drugs & Aging·Omar A Al-MohrejMoin Khan
Sep 19, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Zheng WangMingli Sun

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