PMID: 7538623Jan 1, 1994Paper

The relative essentiality of the antioxidative function of coenzyme Q--the interactive role of DT-diaphorase

Molecular Aspects of Medicine
R E Beyer

Abstract

This paper will address two aspects regarding the antioxidative role of coenzyme Q (CoQ): (1) Is the antioxidant function of CoQ primary or secondary (coincidental), i.e. was this molecule selected during evolution to function primarily as an essential functional component of the mitochondrial electron transfer chain and oxidative phosphorylation processes, is its antioxidative capability merely a coincidence of its hydroquinone structure, or was its synthetic enzyme sequence selected on the basis of the advantage to the evolving organism of both functions of CoQ? (2) What is the mechanism whereby the hydroquinone (antioxidant) form of CoQ (CoQH2) is maintained in high proportion in the various and many membranes in which it resides, and in which an obvious electron transfer mechanism to reduce it is not present? The essentiality of the antioxidative role of CoQH2 will be explored and compared to other primary and secondary antioxidants. Recent evidence implicating the two-electron quinone reductase, DT-diaphorase, in the maintenance of the reduced, antioxidant state of CoQ during the oxidative stress of exhaustive exercise will be presented, and a hypothesis concerning the evolutionary significance of DT-diaphorase will be off...Continue Reading

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C B HugginsA Russo
Nov 23, 1992·FEBS Letters·A ThelinG Dallner
Jun 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·G LenazI Domini
Dec 21, 1992·FEBS Letters·T TakahashiK Goshima
Apr 1, 1992·Chemistry and Physics of Lipids·L LandiG F Pedulli
Jan 1, 1992·Free Radical Research Communications·G MeratiL Landi
Jun 1, 1992·Archives of Biochemistry and Biophysics·F AbergL Ernster
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R StockerB Frei
Jan 1, 1991·Free Radical Research Communications·L LandiL Masotti
Jan 1, 1990·Free Radical Research Communications·B Halliwell
Jan 1, 1990·Free Radical Biology & Medicine·R E Beyer
Feb 15, 1990·The American Journal of Cardiology·P H LangsjoenK Folkers
Nov 1, 1989·Journal of Natural Products·D H WilliamsS K Rahman
Jan 1, 1989·Biomedical Chromatography : BMC·P G ElmbergerG Dallner
Aug 20, 1987·Biochimica Et Biophysica Acta·L LandiL Cabrini
Oct 8, 1987·Biochimica Et Biophysica Acta·A KalénG Dallner
Sep 1, 1984·The Biochemical Journal·L LandiP Pasquali
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P L ChesisB N Ames
Jan 1, 1994·Molecular Aspects of Medicine·E L AppelkvistG Dallner
Aug 1, 1993·The Clinical Investigator·G P Littarru
Jan 1, 1993·The Clinical Investigator·L Ernster, P Forsmark-Andrée
Jan 1, 1993·The Clinical Investigator·J KarlssonK Folkers
Jan 1, 1993·Free Radical Research Communications·D FiorentiniL Landi
Mar 1, 1993·Biochimica Et Biophysica Acta·T ShigemuraN Hamasaki
Jul 1, 1957·Biochimica Et Biophysica Acta·F L CRANEC WIDMER
Feb 18, 1961·Nature·P SESHADRI SASTRYT RAMASARMA
Nov 1, 1963·Archives of Biochemistry and Biophysics·J JAYARAMAN, T RAMASARMA
Jan 1, 1964·The Journal of Experimental Medicine·C HUGGINSE V JENSEN
Jul 1, 1966·Lipids·A Mellors, A L Tappel

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Citations

Jun 13, 2008·Applied Microbiology and Biotechnology·Guangfei LiuYuanyuan Qu
Jan 1, 1990·Free Radical Biology & Medicine·R E Beyer
Jan 1, 1997·Molecular Aspects of Medicine·F L Crane, P Navas
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·R E BeyerG Lenaz
Mar 14, 2000·Redox Report : Communications in Free Radical Research·A K RainaM A Smith
Mar 4, 2005·Critical Reviews in Toxicology·Michelle L O'BrienHoward P Glauert
Oct 26, 2006·Journal of Agricultural and Food Chemistry·Hang Xiao, Kirk Parkin
Dec 18, 2001·Journal of Agricultural and Food Chemistry·L CabriniL Landi
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Kamal Fatima ZahraDaniel Timofte
Apr 7, 2010·Archives of Biochemistry and Biophysics·Albena T Dinkova-Kostova, Paul Talalay

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