The relative potency of amoxycillin and ampicillin in vitro and in vivo

Scandinavian Journal of Infectious Diseases
H Mattie, G B van der Voet

Abstract

The relative antibacterial efficacy of amoxycillin ampicillin was compared in vitro and in vivo against a strain of Escherichia coli in short-term experiments (hours). The quadratic fit to the growth curves in vitro in the presence of the antibiotic gave concentration dependent parameters. The concentration effect curves for both antibiotics showed that amoxycillin varied between equipotent (at 2 mg/l) and twice as potent (at higher concentrations) as ampicillin. The relative efficacy in vivo was determined in a thigh muscle infection in irradiated as well as normal mice. Numbers of colony forming units 3 h after infection were dose (or concentration) dependent, the slopes for amoxycillin and ampicillin being parallel. Slopes in irradiated and non-irradiated mice differed significantly. In both kinds of animals the average potency ratio was 1.5 in favour of amoxycillin. Thus, no difference was found between the in vitro and in vivo situation regarding relative efficacy.

Citations

Mar 18, 2000·International Journal of Antimicrobial Agents·H Mattie
May 1, 1985·British Journal of Clinical Pharmacology·D OverboschR van Furth
Apr 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·H MattieJ Hermans
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·G B van der VoetR van Furth
Feb 1, 1994·British Journal of Clinical Pharmacology·C A VerhagenE Van Strijen
Sep 1, 1988·Antimicrobial Agents and Chemotherapy·W CalameR van Furth
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·J J HoogeterpR van Furth
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·M L van OgtropR van Furth

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