PMID: 8953471Dec 1, 1996Paper

The relative roles of the hypothalamus and cortisol in the control of prolactin gene expression in the anterior pituitary of the sheep fetus

Journal of Neuroendocrinology
I D PhillipsI C McMillen

Abstract

The neuroendocrine control of prolactin synthesis and secretion before birth is not well understood. We have measured the changes in the level of prolactin mRNA in the anterior pituitary of the fetal sheep throughout the last 15 days of pregnancy (term = 147 +/- 3 days gestation). We have also investigated the effects of surgical disconnection of the fetal hypothalamus and pituitary (HPD) with or without long term cortisol infusion on pituitary prolactin mRNA levels and plasma prolactin concentrations in the late gestation sheep fetus. Prolactin mRNA levels were measured in anterior pituitaries collected from a series of fetal sheep (130-134 days, n = 6; 135-140 days, n = 6; 141-145 days, n = 6) in late gestation. HPD was carried out in ten fetal sheep at 105-115 days gestation and five intact fetal sheep were used as controls. In the HPD group, either saline (HPD + saline group, n = 5) or cortisol was infused (3.5 mg/24 h) for 5 days from 134-136 days gestation (HPD + cortisol group, n = 5). There was an increase in the ratio of prolactin mRNA: 18S rRNA in the fetal pituitary between 130-134 days (0.46 +/- 0.08, n = 6) and 135-140 days (1.27 +/- 0.17 n = 6) which was maintained after 141 days gestation, (1.27 +/- 0.11, n = 6)....Continue Reading

References

Jan 1, 1992·Reproduction, Fertility, and Development·J D Curlewis
Jan 1, 1990·Neuroendocrinology·G C AntolovichR Young
Sep 1, 1989·Endocrinology·M Serón-FerréA J Llanos
Mar 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J M BassettJ C Mott
Feb 1, 1995·The Journal of Endocrinology·M FreemarkP A Kelly

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Citations

Sep 26, 2003·The Proceedings of the Nutrition Society·S PearceM E Symond
Jan 30, 2009·Biology of Reproduction·Gerald J PepeEugene D Albrecht
Feb 14, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·L HeasmanM E Symonds
May 19, 2011·FEMS Immunology and Medical Microbiology·Svetoslav N SlavovDimas Tadeu Covas

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