The relative safety of MRI contrast agent in acute necrotizing pancreatitis

Annals of Surgery
J WernerE Klar

Abstract

To validate the safety of gadolinium-diethylenetriamine pentaacetic acid (GD-DTPA) by measuring its effect on pancreatic capillary perfusion and acinar injury in acute pancreatitis. Contrast-enhanced computed tomography (CECT) is proposed as a gold standard for early evaluation of acute necrotizing pancreatitis. However, iodinated contrast media used for CECT have been shown in these circumstances to reduce pancreatic capillary flow and increase necrosis and mortality. Recent reports suggest that post-GD MRI provides images comparable to CECT in the assessment of severe acute pancreatitis. Necrotizing pancreatitis was induced in 14 Wistar rats by intraductal glycodeoxycholic acid (10 mM/L) and intravenous caerulein (5 microg/kg/h) over 6 hours. Intravital microscopic quantitation of pancreatic capillary blood flow was performed using fluorescein isothiocyanate-labeled erythrocytes after induction of pancreatitis and 30 and 60 minutes after an intravenous bolus of either Ringer's solution or GD-DTPA (0.2 mL/kg). The two study groups were comparable with regard to mean arterial pressure, heart rate, arterial blood gases, hematocrit, amylase, lipase, and trypsinogen activation peptide production throughout the experiment. GD-DTPA ...Continue Reading

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Citations

Aug 19, 2009·Topics in Magnetic Resonance Imaging : TMRI·Numan Cem BalciFrank R Burton
Oct 24, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yoshihisa TsujiTsutomu Chiba
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Nov 20, 2002·Journal of Computer Assisted Tomography·Mannudeep K KalraSanjay Saini
Jan 27, 2009·Current Treatment Options in Oncology·Benjamin T GieldaRobert B Cameron

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