The relaxation induced by uroguanylin and the expression of natriuretic peptide receptors in human corpora cavernosa

The Journal of Sexual Medicine
Clauber M SousaNilberto R F Nascimento

Abstract

Receptors for natriuretic peptides have been demonstrated as potential targets for the treatment of male erectile dysfunction. This study investigates the relaxant effects of the atrial natriuretic peptide (ANP) and uroguanylin (UGN), and expression of natriuretic peptide receptors on strips of human corpora cavernosa (HCC). Quantitative analysis of natriuretic receptor expression and relaxation of precontracted strips were used to assess the membrane-bound guanylate cyclase-cyclic guanosine monophosphate (cGMP) pathway in HCC strips. HCC was obtained from a cadaver donor at the time of collection of organs for transplantation (14-47 years) and strips were mounted in organ baths for isometric studies. ANP and UGN both induced concentration-dependent relaxation on HCC strips with a maximal response attained at 300 nM, corresponding to 45.4±4.0% and 49±4.8%, respectively. The relaxation is not affected by 30 µM 1H-[1,2,4]oxaolodiazolo[4,3-a]quinoxalin-1-one (ODQ) (a soluble guanylate cyclase inhibitor), but it is significantly blocked by 10 µM isatin, a nonspecific particulate guanylate cyclase (pGC) inhibitor. UGN was unable to potentiate electrical field stimulation (EFS) or acetylcholine-induced relaxations. The potential role...Continue Reading

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Citations

Jul 24, 2010·The Journal of Pharmacology and Experimental Therapeutics·Iain L O BuxtonStephen D Tichenor
Jan 1, 2013·ISRN Nephrology·Aleksandra Sindic
Dec 3, 2013·Pharmacology, Biochemistry, and Behavior·K DecaluwéJ Van de Voorde
Aug 6, 2011·Canadian Journal of Physiology and Pharmacology·Manassés Claudino Fonteles, Nilberto Robson Falcão do Nascimento
Sep 29, 2011·The Journal of Sexual Medicine·Kelly DecaluwéJohan Van de Voorde
Mar 22, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A A M Lima, M C Fonteles
May 29, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ilan M RuhrMartin Grosell

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