The release mechanism of an oral controlled-release delivery system for indomethacin

Pharmaceutical Development and Technology
M M TalukdarR Kinget

Abstract

This study was carried out to fully characterize the release kinetics of an oral controlled-release tablet formulation of indomethacin with xanthan gum. Matrix swelling, matrix erosion, and drug diffusion studies were performed to elucidate the operative release mechanisms of a tablet compressed from a ternary mixture of indomethacin-xanthan gum-lactose. Drug release tests were performed according to the USP paddle method in phosphate buffer pH 7.4, concurrently with the dissolution of the gum. Mean dissolution time (MDT) of the drug was calculated from the release profile and it was used as a parameter to evaluate the influence of (a) polymer content in the dosage form, (b) ionic strength of the medium, and (c) the rotation speed of the paddle on the release characteristics of the drug. There is a linear relationship between MDT and the inverse of polymer content. Within the range of ionic strength of the gastrointestinal tract, the salt concentration of the dissolution medium has a negative (inhibitory) effect on release rate of the drug and on matrix swelling. A positive (enhancing) influence of the salt concentration on drug diffusion in the hydrated matrices was noted. The polymer dissolution follows almost immediately the...Continue Reading

References

Jul 1, 1993·Pharmaceutical Research·J E Möckel, B C Lippold

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Citations

Nov 29, 2011·Drug Development and Industrial Pharmacy·Ramesh Muthusamy, Mohan Gopalkrishna Kulkarni
Dec 15, 2004·Drug Development and Industrial Pharmacy·Xiaochen GuKeith J Simons
Mar 22, 2003·Drug Development and Industrial Pharmacy·Omaima N El-Gazayerly
Nov 19, 2011·Drug Discovery Today·Przemysław P DorożyńskiGreg J Stanisz
May 22, 2009·International Journal of Pharmaceutics·Hiroaki TasakiKazuhiro Sako
Aug 6, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takayuki YoshidaTakahiro Uchida
Apr 21, 2020·Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics : Materials, Processing, Measurement, & Phenomena : JVST B·Kenneth S OgueriCato T Laurencin

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