The release of gastric inhibitory peptide, glucagon-like peptide-I, and insulin after oral glucose test in colectomized subjects

Scandinavian Journal of Gastroenterology
C Palnaes HansenJ J Holst

Abstract

The physiologic role of the colon as an endocrine organ is not clear. We therefore studied the enteroinsular axis in patients with ulcerative colitis after colectomy. The subjects included 11 patients with a conventional ileostomy, 10 patients with an ileoanal reservoir, and 10 normal controls. The concentrations of glucose, insulin, gastric inhibitory peptide (GIP), and glucagon-like peptide-I (GLP-I) were measured in plasma during an oral glucose test. The peak level of glucose and peak levels and area under the curve (AUC) of insulin and GIP were higher in patients (P < 0.05). Neither the peak level nor the AUC of GLP-I differed between patients and controls, but time to peak level was four times longer in patients with an ileoanal reservoir (P < 0.05). Colectomy seems to affect the enteroinsular axis, leading to hyperinsulinemia and an impaired glucose tolerance. Moreover, patients with an ileoanal reservoir have a slower GLP-I response after intake of glucose.

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Citations

Jun 20, 2007·International Journal of Colorectal Disease·Amosy E M'KomaAlan J Herline
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Dec 23, 2017·Frontiers in Immunology·Lihua DuanJixin Zhong
Jul 31, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Hubert ZatorskiJakub Fichna
Mar 5, 2021·Journal of the Chinese Medical Association : JCMA·Xi-Hsuan LinFa-Yauh Lee
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Sep 19, 2021·Pharmacological Reports : PR·Hubert ZatorskiJakub Fichna

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