PMID: 9425615Jan 13, 1998Paper

The release of immunoreactive interleukin-1 beta from rat hypothalamic explants is modulated by neurotransmitters and corticotropin-releasing hormone

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
G TringaliP Navarra

Abstract

Both constitutive and inducible interleukin-1 (IL-1) gene expressions have been described in the central nervous system, the former being associated with immunoreactive IL-1 neurons in human and rat hypothalami. While most studies have focused on the role of IL-1 as a mediator of pathological events in the brain, the cytokine of neuronal origin might also be involved in the regulation of physiological processes. In this study we used a previously validated technique to investigate the effects of classical neurotransmitters and the hypophysiotropic peptide corticotropin-releasing hormone (CRH) on the release of immunoreactive (ir) IL-1 beta from acute rat hypothalamic explants. We found that basal irIL-1 beta secretion is significantly inhibited by acetylcholine and histamine and increased by dopamine, while dexamethasone, IL-4 and IL-10 have no effect. Moreover, cytokine release is dose-dependently increased by CRH. Such effects of the neurotransmitters and CRH are observed in short-term incubation experiments, indicating that a pre-formed pool of hypothalamic IL-1 beta is involved. These findings also suggest that the interaction between IL-1, neurotransmitters and neuropeptides might play a role in the physiological regulatio...Continue Reading

Citations

Sep 25, 2001·Developmental Psychobiology·M B HennessyP A Schiml-Webb
Aug 9, 2005·International Journal of Behavioral Medicine·Miriam ArgamanShmuel Ariad
Jun 10, 2003·Chembiochem : a European Journal of Chemical Biology·Natalya Lozovaya, Andrew D Miller
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioGlória E P Souza
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioPierluigi Navarra
Jan 26, 2000·Journal of Neurochemistry·L VitkovicC Jacque

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