PMID: 8583380Sep 1, 1995Paper

The release of isoconazole nitrate from different suppository bases: in-vitro dissolution, physicochemical and microbiological studies

The Journal of Pharmacy and Pharmacology
M AsikogluG Cosar

Abstract

The influence of the suppository base on the in-vitro release of isoconazole nitrate was studied by dissolution, physicochemical diffusion and microbiological disk-diffusion methods. Vaginal suppository formulations containing 25 mg isoconazole nitrate for local treatment of vaginitis were prepared by a fusion method, using different hydrophilic and lypophilic suppository bases (PEG 6000, PEG 4000, PEG 1500, Witepsol H15, Novata BD and Cremao). In-vitro release rates were examined by dissolution, physicochemical diffusion and microbiological disk-diffusion methods. In the physicochemical investigations the pH indicators (pH 1-14) erythrosin B, thymol blue, bromocresol green, chlorophenol red, phenol red, and alkali blue were added to agar gels. The discs were placed onto the agar gels and 21 h later, the coloured zone diameters were measured. In the microbiological investigations, the discs were put on the inoculated plates with the suspension of Candida albicans (Institute Pasteur 628). The inoculated plates were incubated at 37 degrees C for 3 days, then the diameters of inhibition zones were measured. In the dissolution investigations release rates were in the order PEG 6000 > PEG 4000 > PEG 1500 > > Witepsol H15 > Cremao > ...Continue Reading

References

May 1, 1975·Journal of Pharmaceutical Sciences·E L Parrott
Jul 1, 1975·Journal of Pharmaceutical Sciences·I W Kellaway, C Marriott
Dec 1, 1985·Genitourinary Medicine·C S Bradbeer, R N Thin
Feb 1, 1973·Journal of Pharmaceutical Sciences·H W Puffer, W J Crowell
Jul 1, 1967·Journal of Pharmaceutical Sciences·J M PlaxcoC R Rowland
Jun 1, 1981·Journal of Pharmaceutical Sciences·T J RosemanS S Butler
Jun 1, 1959·Journal of the American Pharmaceutical Association·C W WHITWORTH, J P LAROCCA

❮ Previous
Next ❯

Citations

Nov 10, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T K Mandal
May 20, 2008·Pharmaceutical Development and Technology·Makbule AsikoğluHayal Ozkilic
Apr 25, 2007·Drug Delivery·Ozgen OzerKamil Köseoglu
Apr 25, 2014·Drug Delivery·Amal El Sayeh F Abou el ElaEhsan H Ibrahim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
M AmeriC Booth
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
S KüknerO Gökmen
© 2021 Meta ULC. All rights reserved