The release of metals from metal-on-metal surface arthroplasty of the hip

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Ivo IavicoliGiovanni Carelli

Abstract

The aim of the study was to evaluate the serum and urine levels of cobalt (Co), chromium (Cr), manganese (Mn), molybdenum (Mo) and nickel (Ni) in patients who had undergone metal-on-metal hybrid surface arthroplasties on the supposition that a release of metals would occur due to the large head size of this type of implant. Metal levels were determined by using an analytical method based on sector field inductively coupled plasma mass spectrometry. Results showed a significant difference between patients and control subjects in mean levels of Co and Cr in serum (p<0.0001 and p=0.02, respectively) and in urine (p<0.0001 for both). No significant differences were observed in mean serum and urinary levels of Mn, Mo and Ni. Although the clinical consequences of these changes, if any, are unknown, further studies could be performed in a larger number of subjects implanted with a total surface arthroplasty at follow-up times over different periods.

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Citations

Jun 14, 2008·Der Orthopäde·C HeiselJ P Kretzer
Oct 25, 2008·Analytical and Bioanalytical Chemistry·Alejandro Sarmiento-GonzálezAlfredo Sanz-Medel
Oct 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Henri MigaudJulien Girard
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Jun 5, 2019·Parasites & Vectors·Ayaz AnwarNaveed Ahmed Khan
Jul 7, 2011·Human & Experimental Toxicology·S CatalaniP Apostoli

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