The release of prostaglandin E1 from the rat phrenic nerve-diaphragm preparation

British Journal of Pharmacology
J L Laity

Abstract

1. The release of prostaglandin E(1) from the rat phrenic nerve-diaphragm preparation during tetanic contraction of the muscle in response to nerve stimulation is reported. Tentative identification of the prostaglandin depended on solvent extraction column and thin-layer chromatography and parallel biological assay.2. Polar lipid substances were released from the preparation in the absence of nerve stimulation by (+)-tubocurarine and noradrenaline.3. The output on nerve stimulation was not abolished by (+)-tubocurarine, hemicholinium, bretylium or phenoxybenzamine added to the bath.4. The possible origin of these prostaglandins is discussed.

References

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Nov 1, 1975·European Journal of Pharmacology·W J HallJ D Sheehan
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Sep 22, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·M W GreavesR G McDonald-Gibson

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