The release of prostaglandin E1 from the rat phrenic nerve-diaphragm preparation

British Journal of Pharmacology
J L Laity


1. The release of prostaglandin E(1) from the rat phrenic nerve-diaphragm preparation during tetanic contraction of the muscle in response to nerve stimulation is reported. Tentative identification of the prostaglandin depended on solvent extraction column and thin-layer chromatography and parallel biological assay.2. Polar lipid substances were released from the preparation in the absence of nerve stimulation by (+)-tubocurarine and noradrenaline.3. The output on nerve stimulation was not abolished by (+)-tubocurarine, hemicholinium, bretylium or phenoxybenzamine added to the bath.4. The possible origin of these prostaglandins is discussed.


Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·B N DaviesP G Withrington
Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·E W Horton, I H Main
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·J R VANE

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Nov 1, 1975·European Journal of Pharmacology·W J HallJ D Sheehan
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I KimuraM Kimura
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T AkasuT Tokimasa
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L Levine, M A Moskowitz
Jul 1, 1976·British Journal of Pharmacology·J GripenbergE M Tolppanen
Apr 1, 1971·Acta Physiologica Scandinavica·E Anggård, C E Jonsson
Jul 1, 1971·Acta Physiologica Scandinavica·E Anggård, K Strandberg
Sep 1, 1971·Journal of Neurochemistry·L L Simpson, M M Rapport
Apr 30, 1971·Annals of the New York Academy of Sciences·P Piper, J Vane
Apr 30, 1971·Annals of the New York Academy of Sciences·F CoceaniB Lavers
Sep 22, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·M W GreavesR G McDonald-Gibson

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