The release of spasmogenic substances from human chopped lung tissue and its inhibition

British Journal of Pharmacology
P J Piper, J L Walker


1. Human lung tissue, passively sensitized with reaginic antibodies, released prostaglandins E(1), E(2) and F(2alpha) in addition to histamine and slow reacting substance (SRS-A), when exposed to the appropriate antigen. No rabbit aorta contracting substance (RCS) was detected.2. Experiments with rats and guinea-pigs showed that the release of RCS is not confined to anaphylactic reactions mediated by non-reaginic antibodies but may be a feature of anaphylaxis in guinea-pigs alone.3. Human lung tissue gently agitated with a blunt nylon rod liberated an E-type prostaglandin and RCS in addition to histamine and SRS-A.4. Human isolated bronchial muscle was contracted by RCS.5. Disodium cromoglycate antagonized the release of prostaglandins during anaphylaxis but not during agitation of human lung tissue, whereas indomethacin blocked the release of prostaglandins during agitation and anaphylaxis.6. The release of an E-type prostaglandin during anaphylaxis in human lung tissue, which inhibits the further release of histamine could be another example of the regulatory role of prostaglandins in body functions.


May 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·W J KoopmanK F Austen
Apr 30, 1971·Annals of the New York Academy of Sciences·P Piper, J Vane
Jan 1, 1969·Physiological Reviews·E W Horton
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Feb 1, 1964·British Journal of Pharmacology and Chemotherapy·E W HORTON, C J THOMPSON
Apr 1, 1964·British Journal of Pharmacology and Chemotherapy·H P RANG

❮ Previous
Next ❯


Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·W Dorsch, L Frey
Apr 28, 1976·Molecular and Cellular Biochemistry·K Strandberg, S Westerberg
Jul 1, 1976·Agents and Actions·E Anggard, E Oliw
Jul 1, 1976·Agents and Actions·P J Piper
Jul 1, 1976·Agents and Actions·S I Said
Mar 7, 1980·European Journal of Pharmacology·F Al-Ubaidi, Y S Bakhle
Dec 1, 1981·Prostaglandins·E W SpannhakeP J Kadowitz
Feb 1, 1986·Prostaglandins·Y D FannA B DuBois
Sep 1, 1973·The Journal of Allergy and Clinical Immunology·J B RichardsonD L Hall
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Jan 1, 1980·International Journal of Immunopharmacology·P Sirois, P Borgeat
Oct 1, 1983·Prostaglandins, Leukotrienes, and Medicine·K G Rothberg, M Hitchcock
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M N Samhoun, P J Piper
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·P J Piper
Jan 1, 1984·General Pharmacology·S A Al-NagdyS E Warraki
Apr 21, 1977·The New England Journal of Medicine·A A MathéC A Leslie
Aug 1, 1975·British Journal of Clinical Pharmacology·A P Smith
Nov 1, 1977·International Journal of Dermatology·M E Goldyne
Aug 1, 1975·British Journal of Pharmacology·L S Dunlop, A P Smith
Sep 1, 1975·British Journal of Pharmacology·J B FarmerA M Woods
May 1, 1975·Acta Physiologica Scandinavica·K Strandberg, P Hedqvist
Oct 1, 1987·The American Review of Respiratory Disease·J S Douglas, C Brink
Apr 1, 1984·Environmental Health Perspectives·T E Eling, A I Ally
Sep 1, 1984·The American Journal of the Medical Sciences·J H Newman, J R Sheller
Dec 1, 1973·Clinical Allergy·R P Orange
Dec 1, 1973·Clinical Allergy·J Pepys
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·R A Lewis, J L Robin
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·B G Simonsson, N Svedmyr
Jan 1, 1980·The Journal of Surgical Research·V P Addonizio, A H Harken
Sep 1, 1979·Pharmacological Research Communications·G C FolcoF Berti
Jan 1, 1982·Equine Veterinary Journal·C J HannaD G McBeath

❮ Previous
Next ❯

Related Concepts

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.