The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers

Journal of Hypertension
A OhtaharaC Shigemasa

Abstract

Hyperuricemia is associated with the vascular injury of hypertension, and purine oxidation may play a pivotal role in this association, but the pathophysiology is not fully understood. We tested the hypothesis that in hypertensive patients, the excess amount of the purine metabolite, hypoxanthine, derived from skeletal muscles, would be oxidized by xanthine oxidase, leading to myogenic hyperuricemia as well as to impaired vascular resistance caused by oxygen radicals. We investigated the production of hypoxanthione, the precursor of uric acid and substrate for xanthine oxidase, in hypertensive patients and found that skeletal muscles produced hypoxanthine in excess. We used the semi-ischemic forearm test to examine the release of hypoxanthine (deltaHX), ammonium (deltaAmm) and lactate (deltaLAC) from skeletal muscles in essential hypertensive patients before (UHT: n = 88) and after treatment with antihypertensive agents (THT: n = 37) in comparison to normotensive subjects (NT: n = 14). deltaHX, as well as deltaAmm and deltaLAC, were significantly higher in UHT and THT (P< 0.01) than in NT. This release of deltaHX from exercising skeletal muscles correlated significantly with the elevation of lactate in NT, UHT and THT (y = 0.20...Continue Reading

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Citations

Sep 1, 2004·Histochemistry and Cell Biology·R M Touyz, E L Schiffrin
Mar 21, 2012·Antioxidants & Redox Signaling·Daniela Zablocki, Junichi Sadoshima
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshihiro HamadaIchiro Hisatome
Aug 1, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasutaka YamamotoIchiro Hisatome
Jun 12, 2012·Clinical and Experimental Hypertension : CHE·Toshihiro HamadaIchiro Hisatome
Jan 18, 2014·Clinical and Experimental Hypertension : CHE·Satoshi MiyazakiIchiro Hisatome
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Rhian M Touyz
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Paolo Abrescia, Paolo Golino
Sep 30, 2020·Hormone Molecular Biology and Clinical Investigation·Kazheen Hussein JawzalDeldar Morad Abdulah
Dec 4, 2014·Physiological Research·W DudzinskaM Janiak

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