The relevance of beta-receptor blockade to ouabain-induced cardiac arrhythmias

British Journal of Pharmacology
A N DohadwallaE M Vaughan Williams

Abstract

1. (+)-propranolol and (+/-)-propranolol are comparable in their potency as a local anaesthetic on the intact and desheathed frog sciatic nerve.2. (+/-)-propranolol is much more potent than (+)-propranolol as a beta-receptor blocking agent and also more effective than the latter in protecting guinea-pigs against ouabain-induced ventricular fibrillation.3. In isolated rabbit atria (-)-, (+)- and (+/-)-propranolol, and I.C.I. 50172, which has hardly any local anaesthetic activity, greatly reduce the rate of rise of the intracellularly recorded action potential at concentrations which have no significant effect on electrical threshold, contractions, spontaneous frequency, maximum driving frequency, repolarization time or conduction velocity.

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Related Concepts

Nerve Impulses
Neural Therapy of Huneke
Metazoa
Salientia
Cardiac Arrhythmia
Cavia porcellus
Right Atrial Structure
Pulse Rate
Ouabain
Rexigen

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