The relevance of ceramides and their synthesizing enzymes for multiple sclerosis

Clinical Science
Jennifer KurzSusanne Schiffmann

Abstract

Ceramide synthases (CerS) synthesize chain length specific ceramides (Cer), which mediate cellular processes in a chain length-dependent manner. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we observed that the genetic deletion of CerS2 suppresses EAE pathology by interaction with granulocyte-colony stimulating factor (G-CSF) signaling and CXC motif chemokine receptor 2 (CXCR2) expression, leading to impaired neutrophil migration. In the present study, we investigated the importance of Cers and their synthesizing/metabolizing enzymes in MS. For this purpose, a longitudinal study with 72 MS patients and 25 healthy volunteers was performed. Blood samples were collected from healthy controls and MS patients over 1- or 3-year periods, respectively. Immune cells were counted using flow cytometry, ceramide levels were determined using liquid chromatography-tandem mass spectrometry, and mRNA expression was analyzed using quantitative PCR. In white blood cells, C16-LacCer and C24-Cer were down-regulated in MS patients in comparison with healthy controls. In plasma, C16-Cer, C24:1-Cer, C16-GluCer, and C24:1-GluCer were up-regulated and C16-LacCer was down-regulated in MS patients in com...Continue Reading

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Citations

Mar 9, 2019·Journal of Lipid Research·Jeffrey L StithLina M Obeid
Oct 4, 2019·Journal of Diabetes Investigation·Yoshifumi MoritaYutaka Yatomi
Jul 7, 2019·Journal of Clinical Medicine·Sarah BazarganipourSabine Grösch
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Jul 13, 2020·Neurobiology of Disease·Devesh C PantAurora Pujol
Jan 16, 2021·Frontiers in Neuroendocrinology·Daniel Báez CastellanosJanneth González
May 1, 2019·Journal of Lipid Research·Jeffrey L StithLina M Obeid
Jun 10, 2020·Multiple Sclerosis and Related Disorders·Helena Beatriz FerreiraM Rosário Domingues
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Nov 16, 2020·Archives of Biochemistry and Biophysics·Helena Beatriz FerreiraM Rosário Domingues
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Jul 3, 2021·Biomolecules·Antía CustodiaAlberto Ouro
Jul 25, 2021·International Journal of Molecular Sciences·Maria PodbielskaAnna Pokryszko-Dragan

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