The relevance of cytokines in the radiation-induced lung reaction. Experimental basis and clinical significance

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Claudia E RübeChristian Rübe

Abstract

The radiosensitivity of the lung tissue limits the dose of radiation which can be delivered to tumors in the thoracic region. Radiation-induced lung damage implies the induction of numerous cytokines which form the basis for the multicellular interactions of the inflammatory and fibrogenic processes associated with radiation injury. It is of special clinical significance, how far local radiation induced cytokine production in the lung tissue may be reflected in increased cytokine blood levels in patients during radiotherapy and may predict the later development of radiation-induced lung damage. Another potential cause of increased cytokine levels in the blood of oncologic patients is the secretion of cytokines in the blood circulation by tumor specimens. Published data on radiation-induced cytokine expression from experimental and clinical studies are reviewed. The major pro-inflammatory cytokines in the radiation response of the lung include tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6). Transforming growth factor-beta (TGF-beta) appears to be of particular importance in the development of lung fibrosis. First approaches with radioprotective agents and gene therapy to modify radiation-...Continue Reading

Citations

Aug 7, 2008·PloS One·Claudia E RübeChristian Rübe
Mar 8, 2013·PloS One·Dipankar RayTheodore S Lawrence
Aug 23, 2008·World Journal of Gastroenterology : WJG·Ki-Tae KimSuk-Jin Kang
Jul 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Klaus-Rüdiger TrottVere Smyth
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jung-Yien ChienPan-Chyr Yang
Aug 31, 2007·International Journal of Radiation Biology·Kunyu YangClaudia E Rübe
Mar 13, 2009·International Journal of Radiation Biology·Ulrike C KuhlmannFrank Buhling
Aug 6, 2011·Journal of Cancer Research and Clinical Oncology·Shigeki UmemuraHaruhito Kamei

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