The relevance of intestinal dysbiosis in liver transplant candidates

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Michał GrątMarek Krawczyk

Abstract

The gut microbial ecosystem plays an important role in the pathogenesis of liver diseases. However, the association of microbial community structure with the severity of liver dysfunction is not completely understood. Fecal microflora was assessed in 40 patients with liver cirrhosis listed for primary liver transplantation (LT). Independent associations between fecal microbial counts and serum bilirubin, serum creatinine, international normalized ratio (INR), and the Model for End-stage Liver Disease (MELD) score were established in multiple linear regression models. Bifidobacterium (standardized regression coefficient [sβ] = -0.549; P < 0.001), Enterococcus (sβ = 0.369; P = 0.004), and yeast (sβ = 0.315; P = 0.018) numbers were independently associated with serum bilirubin, while Escherichia coli counts (sβ = 0.318; P = 0.046) correlated with INR, and Bifidobacterium counts (sβ = 0.410; P = 0.009) with serum creatinine. Only Bifidobacterium (sβ = -0.468; P = 0.003) and Enterococcus (sβ = 0.331; P = 0.029) counts were independent predictors of the MELD score. Bifidobacterium/Enterococcus ratio, proposed as a measure of pre-LT gut dysbiosis, was significantly related to the MELD score following the adjustment for the absolute Bi...Continue Reading

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Citations

May 10, 2017·The Journal of Clinical Investigation·Leonardo V RiellaMaria-Luisa Alegre
Jun 11, 2017·Physiological Genomics·Matthew R PanasevichR Scott Rector
Oct 11, 2016·World Journal of Hepatology·Mamatha BhatJohane P Allard
Jun 21, 2017·Scientific Reports·Li-Ying SunZhi-Gui Zeng
Mar 13, 2018·World Journal of Hepatology·Alberto FerrareseMarco Senzolo

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