The relevance of salicylic acid in the treatment of plaque psoriasis with dithranol creams.

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
S de MareP C Van De Kerkhof

Abstract

The relevance of salicylic acid in dithranol creams was evaluated in a double-blind study. Patients with chronic plaque psoriasis were treated using a short-contact schedule for dithranol on an outpatient basis. A left-right comparison was carried out between sites treated with either dithranol with 2% salicylic acid (D + S) or dithranol in the same base without salicylic acid (D-S). Clinical results were evaluated once a week using the psoriasis area severity index. In order to quantify the improvement, flow cytometric measurements were done using the monoclonal antibody Ks8.12, recognizing keratin 16 in normal and lesional epidermis. Simultaneously, relative DNA content was quantified which previously was described as a useful method to monitor a therapeutic effect. Both PASI scores and Ks8.12 binding decreased after 6 weeks treatment with D + S and D-S. However, percentages of cells in SG2M phases did not show a significant change. No significant difference was observed between sites treated with either D + S or D-S. Therefore we conclude that the addition of salicylic acid in a concentration of 2% does not enhance the efficacy of dithranol creams and we confirm that Ks8.12 is a useful quantitative marker for therapeutic eff...Continue Reading

Citations

Jan 1, 1991·Archives of Dermatological Research·B FarkasG Mahrle
May 15, 2007·Archives of Dermatological Research·A NastB Rzany
Feb 22, 2012·Archives of Dermatological Research·A NastUNKNOWN Berufsverband Deutscher Dermatologen
Oct 6, 1997·Clinics in Dermatology·G Mahrle
Jan 1, 1991·Archives of Dermatological Research·E M de JongP C van de Kerkhof
Oct 20, 2010·Cutaneous and Ocular Toxicology·Tarek A Shazly
Dec 26, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Germany Society for Dermatology
Jul 11, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Berufsverband Deutscher Dermatologen (BVDD)
Jul 12, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A G M HendriksP C M van de Kerkhof
Apr 12, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Berufsverband Deutscher Dermatologen (BVDD)

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