The relevance of some laboratory tests in the diagnosis of cholestasis and the differentiation between intra- and extrahepatic obstruction

Clinica Chimica Acta; International Journal of Clinical Chemistry
T KruiswijkM Szakaly

Abstract

The Lp-X test and the determination of total gammaglutamyltransferase activity (GGT), its isoenzyme activities (GGT-1 and GGT-2) and the bile acids have been performed in sera obtained from 66 patients with and without cholestasis. The sensitivity of the Lp-X test as an indicator for cholestasis appeared to be 89% with a specificity of 94%. With the exception of GGT-2 activity, the mean values of total GGT, GGT-1 isoenzyme and bile acids differed significantly between the cholestasis positive and negative groups. The diagnostic use of total GGT, isoenzymes and bile acids in the differentiation between intrahepatic cholestasis and extrahepatic biliary obstruction has been investigated. The GGT-1 isoenzyme activity appeared to be the only parameter differing significantly between the two forms of cholestasis.

References

Feb 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·C P DegenaarG T Berends
Apr 3, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·R FellinM Rugge
Jun 1, 1975·Journal of Clinical Pathology·S BarnesJ S Morris
Jan 24, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·O Azzopardi, M F Jayle
Aug 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Miyazaki, M Okumura
Sep 19, 1969·Deutsche medizinische Wochenschrift·G SzaszW Fritzsche

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Citations

Jun 14, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Schut, D P Diaz
Jul 23, 2004·Journal of Pediatric Gastroenterology and Nutrition·Virginia MoyerUNKNOWN North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SörösM J Müller

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