The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review

Nutrients
Akiko Sakasai-SakaiMasayoshi Takeuchi

Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently the most common feature of chronic liver disease. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD, and one of its risk factors is hyperglycemia. The chronic ingestion of excessive amounts of high-fructose corn syrup is associated with an increased prevalence of fatty liver. Under hyperglycemic conditions, advanced glycation end-products (AGEs) are generated through a non-enzymatic glycation reaction between the ketone or aldehyde groups of sugars and amino groups of proteins. Glyceraldehyde (GA) is a metabolic intermediate of sugars, and GA-derived AGEs (known as toxic AGEs (TAGE)) have been implicated in the development of NASH. TAGE accumulates more in serum or liver tissue in NASH patients than in healthy controls or patients with simple steatosis. Furthermore, the TAGE precursor, GA, causes cell damage through protein dysfunctions by TAGE modifications and induces necrotic-type hepatocyte death. Intracellular TAGE may leak outside of necrotic-type cells. Extracellular TAGE then induce inflammatory or fibrotic responses related to the pathology of NASH in surrounding cells, including hepatocytes and hepatic stellate cells. This review focuses on the contri...Continue Reading

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Citations

Dec 27, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Evelyn Nunes Goulart da Silva PereiraAnissa Daliry
Jul 15, 2020·International Journal of Molecular Sciences·Akiko Sakasai-SakaiMasayoshi Takeuchi
Jul 19, 2019·Nutrients·Takanobu TakataMasayoshi Takeuchi
Oct 17, 2019·International Journal of Molecular Sciences·Dinali H FernandoChandana B Herath
Jul 21, 2020·Diabetology & Metabolic Syndrome·Takanobu TakataMasayoshi Takeuchi
Apr 4, 2021·Biomolecules·Masayoshi TakeuchiTamihide Matsunaga
May 15, 2021·Cell·Rohit LoombaGerald I Shulman
Aug 28, 2021·World Journal of Gastroenterology : WJG·Evelyn Nunes Goulart da Silva PereiraRosane Harter Griep
Oct 28, 2021·Journal of Agricultural and Food Chemistry·Agustin Martin-MoralesKenji Sato

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