PMID: 2905750Jan 1, 1988Paper

The relevance to clinical care of recent research in neurobiology

Journal of Substance Abuse Treatment
J Wallace

Abstract

Progress continues to be made in clarifying neurobiological factors in alcoholism and other chemical dependencies. Research in animal behavioral genetics and human genetics has revealed substantial genetic predispositions for some cases of alcoholism. Studies of neurotransmitters suggest that some alcoholics may have antecedent deficiencies in one or more important neurochemical systems. Cocaine dependence is considered to be related to biphasic change in dopaminergic neurons and receptor systems. Condensation products such as salsolinol, tetrahydropapaveroline, and beta carbolines can alter alcoholic preference and motivate heavy ethanol consumption in animals. However, hypothesized theoretical mechanisms underlying such increased drinking with infusions of condensation products are unclear and may require revision. New pharmacological treatments stemming from advances in neurobiological research have been applied successfully to treatment of withdrawal states, but none have been demonstrated to be appropriate for long-term maintenance of abstinence.

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Citations

May 1, 1993·Journal of Substance Abuse Treatment·E J Chiauzzi, S Liljegren
Apr 1, 1989·Journal of Psychoactive Drugs·J Wallace
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·R Z Litten, J P Allen
Jan 1, 1992·Journal of Substance Abuse·A ToneattoM B Sobell
Feb 1, 1995·The American Journal of Drug and Alcohol Abuse·M T French
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May 1, 1997·The American Journal of Drug and Alcohol Abuse·G De LeonD Kressel
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Dec 6, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Michael T. FrenchDuane McBride
Sep 1, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·A Thomas McLellan
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Jan 1, 1995·Journal of Psychoactive Drugs·G De Leon
Mar 16, 2012·Substance Use & Misuse·Roya NooriBabak Khoshkrood Mansoori

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