The reliability-engineering approach to the problem of biological aging

Annals of the New York Academy of Sciences
Leonid A Gavrilov, Natalia S Gavrilova

Abstract

We applied reliability theory to explain aging of biological species and came to the following conclusions: (1) Redundancy is a key notion for understanding aging and the systemic nature of aging in particular. Systems, which are redundant in numbers of irreplaceable elements, do deteriorate (i.e., age) over time, even if they are built of nonaging elements. (2) An apparent aging rate or expression of aging (measured as age differences in failure rates, including death rates) is higher for systems with higher redundancy levels. (3) Redundancy exhaustion over the course of life explains the observed compensation law of mortality (mortality convergence at later life) as well as the observed late-life mortality deceleration, leveling-off, and mortality plateaus. (4) Living organisms seem to be formed with a high load of initial damage, and therefore their life span and aging patterns may be sensitive to early-life conditions that determine this initial damage load during early development.

References

Dec 18, 2001·Journal of Theoretical Biology·L A Gavrilov, N S Gavrilova
Jun 14, 2003·TheScientificWorldJournal·Leonid A Gavrilov, Natalia S Gavrilova
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Aubrey D N J de Grey
Jul 18, 2003·Science of Aging Knowledge Environment : SAGE KE·Leonid A Gavrilov, Natalia S Gavrilova

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Citations

Jan 5, 2008·Biogerontology·Pedro Alexandre FigueiredoJosé Alberto Duarte
Jul 2, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedKaren Bandeen-Roche
Mar 6, 2008·Annual Review of Biochemistry·Michael P Murphy, Linda Partridge
Aug 13, 2008·Expert Opinion on Biological Therapy·E CeveniniC Franceschi
Apr 7, 2009·Biochimica Et Biophysica Acta·Alexander Y Maslov, Jan Vijg
Oct 24, 2007·Medical Hypotheses·Walter E Lowell, George E Davis
Oct 20, 2006·Experimental Gerontology·Eva TerzibasiAlessandro Cellerino
Oct 24, 2006·Medical Hypotheses·Armin Shmilovici
Jan 19, 2018·Annual Review of Clinical Psychology·Tim A Ahles, James C Root
Jan 21, 2020·Frontiers in Physiology·Tamas FulopJacek M Witkowski
Nov 26, 2009·Rejuvenation Research·Leonid A Gavrilov, Natalia Gavrilova
May 18, 2010·Journal of Proteome Research·Lei MaoClaus Zabel
Aug 10, 2021·Journal of Geriatric Oncology·Tim A AhlesArti Hurria
May 19, 2021·Pediatrics·Laurel RaffingtonK Paige Harden

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