The reliability of 5-hydroxytryptamine induced platelet aggregation responses in schizophrenic patients treated with neuroleptic drugs

British Journal of Clinical Pharmacology
J M KnoxD G Grahame-Smith

Abstract

1 The reliability of 5-hydroxytryptamine induced platelet aggregation responses in psychiatric patients treated with neuroleptic drugs was investigated by examining the effects of a number of technical factors which could account for the variability of responses observed in some patients. 2 Variation in incubation time, temperature, aggregometer stirrer speed, and in the time interval between withdrawal of the blood sample and testing, had no significant effects on the consistency of responses. 3 Dilution of platelet rich plasma (PRP) led to enhanced platelet aggregation responses becoming non-enhanced. 4 Overcentrifugation of blood samples during the preparation of PRP caused a decrease in the incidence of enhanced platelet aggregation responses observed in chronic schizophrenic patients receiving chlorpromazine. 5 The reliability of platelet aggregation responses as indices of the action of neuroleptic drugs in psychiatric patients remains doubtful.

References

Dec 1, 1978·British Journal of Clinical Pharmacology·D J BoullinD G Grahame-Smith
Feb 1, 1975·British Journal of Clinical Pharmacology·D J BoullinD G Grahame-Smith
Mar 1, 1981·British Journal of Clinical Pharmacology·M W OrrD G Grahame-Smith

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Citations

Mar 1, 1981·British Journal of Clinical Pharmacology·A V Mackay
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·M L Tiffany
Apr 1, 1985·British Journal of Clinical Pharmacology·M SchächterJ M Elliott

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