The remote ischemic preconditioning algorithm: effect of number of cycles, cycle duration and effector organ mass on efficacy of protection

Basic Research in Cardiology
Jacob JohnsenHans E Bøtker

Abstract

Remote ischemic preconditioning (rIPC), induced by cycles of transient limb ischemia and reperfusion (IR), is cardioprotective. The optimal rIPC-algorithm is not established. We investigated the effect of cycle numbers and ischemia duration within each rIPC-cycle and the influence of effector organ mass on the efficacy of cardioprotection. Furthermore, the duration of the early phase of protection by rIPC was investigated. Using a tourniquet tightened at the inguinal level, we subjected C57Bl/6NTac mice to intermittent hind-limb ischemia and reperfusion. The rIPC-protocols consisted of (I) two, four, six or eight cycles, (II) 2, 5 or 10 min of ischemia in each cycle, (III) single or two hind-limb occlusions and (IV) 0.5, 1.5, 2.0 or 2.5 h intervals from rIPC to index cardiac ischemia. All rIPC algorithms were followed by 5 min of reperfusion. The hearts were subsequently exposed to 25 min of global ischemia and 60 min of reperfusion in an ex vivo Langendorff model. Cardioprotection was evaluated by infarct size and post-ischemic hemodynamic recovery. Four to six rIPC cycles yielded significant cardioprotection with no further protection by eight cycles. Ischemic cycles lasting 2 min offered the same protection as cycles of 5 mi...Continue Reading

References

Aug 1, 1990·Circulation·G C LiB R Lucchesi
Apr 1, 1993·Cardiovascular Research·S SackW Schaper
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Mar 1, 1997·Journal of Molecular and Cellular Cardiology·E K IliodromitisD J Hearse
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B GünaydinY Karadenizli
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
Dec 4, 2002·Circulation·R K KharbandaR MacAllister
May 27, 2005·The Journal of Surgical Research·Yih-Sharng ChenChau-Fong Chen
Jun 25, 2009·Journal of Cardiac Surgery·Pankaj SaxenaIgor E Konstantinov
Mar 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Ping XinAndrew N Redington
May 8, 2010·Basic Research in Cardiology·Shiang Y LimDerek J Hausenloy
May 25, 2010·Cardiovascular Drugs and Therapy·Derek J Hausenloy, Derek M Yellon
Jun 24, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Qingping WuShanglong Yao
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Karin Przyklenk, Peter Whittaker
Mar 9, 2012·Cardiology Research and Practice·Kristin Veighey, Raymond J Macallister
Mar 20, 2012·Basic Research in Cardiology·Derek J Hausenloy, Derek M Yellon
Sep 12, 2012·Journal of Cardiovascular Medicine·Karin Przyklenk, Peter Whittaker
Sep 18, 2012·Life Sciences·Gordon Tin Chun WongMichael G Irwin
Aug 3, 2013·Circulation Research·Michel OvizeKarin Przyklenk
Aug 7, 2013·Basic Research in Cardiology·Sean M DavidsonDerek M Yellon
Oct 22, 2013·Journal of Molecular and Cellular Cardiology·Hussein KalakechFabrice Prunier
Feb 15, 2014·The Journal of Surgical Research·Kentaro YamakawaAman Mahajan
Mar 20, 2014·Circulation Research·Tienush RassafMalte Kelm
May 6, 2014·The American Journal of Cardiology·Theodoros A ZografosDemosthenes G Katritsis
Jul 26, 2014·Basic Research in Cardiology·Jing LiAndrew N Redington
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Peter Whittaker, Karin Przyklenk

❮ Previous
Next ❯

Citations

Apr 5, 2017·Journal of Cellular and Molecular Medicine·Sean M DavidsonDerek M Yellon
Jun 21, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·John C Quindry
Nov 3, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kasper PrydsHans Erik Bøtker
Mar 3, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Hans Erik BøtkerNichlas Riise Jespersen
Mar 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Marie HauerslevMichael Rahbek Schmidt
Apr 30, 2017·Circulation Research·Gerd Heusch
Oct 13, 2018·Tissue Engineering. Part a·Timothy Chen, Gordana Vunjak-Novakovic
Jan 1, 2019·Experimental Physiology·Justin D SprickCaroline A Rickards
Dec 5, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Flávia de Sousa GehrkeMarcelo Rodrigues Bacci
Apr 27, 2020·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
Jun 29, 2017·International Journal of Sports Physiology and Performance·Scott CockingHelen Jones
May 10, 2017·Clinical Hemorheology and Microcirculation·J KolbenschlagM Lehnhardt
Aug 19, 2018·Basic Research in Cardiology·Hans Erik BøtkerGerd Heusch
Mar 9, 2019·Annals of Clinical and Translational Neurology·Linlin GuoRan Meng
Jul 6, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yasmin El DabaghToke Bek
Jun 14, 2019·Dose-response : a Publication of International Hormesis Society·Hoon JungDong Gun Lim
Aug 25, 2018·Dose-response : a Publication of International Hormesis Society·Rehana K LeakMelvin E Andersen
Sep 19, 2020·Interventional Cardiology·Joel P Giblett, Heerajnarain Bulluck
May 16, 2017·F1000Research·Luciano Candilio, Derek Hausenloy
May 26, 2018·European Journal of Applied Physiology·Tiago TurnesFabrizio Caputo
Apr 7, 2019·European Journal of Applied Physiology·Joshua T Slysz, Jamie F Burr
Mar 28, 2019·Experimental Brain Research·Anna E MattlageCatherine E Lang
Apr 3, 2019·Basic Research in Cardiology·Georgios AmanakisAndreas Skyschally

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.