PMID: 2505695Jul 1, 1989Paper

The removal of strontium from the mouse by chelating agents

Archives of Environmental Contamination and Toxicology
A OrtegaJ Corbella

Abstract

The effects of the chelating agents monosodium glutamate, Tiron, tartaric acid, ascorbic acid, 1,4,7,10,13,16-hexaoxacyclooctadecane (18-crown-6), 2,3-dimercaptosuccinic acid (DMSA), succinic acid, malic acid, ethylendiaminetetraacetic acid (EDTA), ethylenglycol-bis-(beta-amino-ethylether)-N,N'tetraacetic acid (EGTA), cyclohexane-diaminetetraacetic acid (CDTA) and diethylentria-minepentaacetic acid (DTPA) on the distribution and excretion of intraperitoneally injected strontium were investigated in male Swiss mice. Strontium nitrate was given at a dose equal to 3.78 mmol/kg and ten minutes after, chelators were administered intraperitoneally at doses approximately equal to one-fourth of their respective LD50 values. DTPA, followed by CDTA, EDTA and tartaric acid, was consistently the most effective in increasing the urinary excretion of strontium. Only ascorbic acid increased significantly the fecal excretion of strontium. CDTA, DTPA and ascorbic acid were also the most effective chelators in reducing the concentration of strontium found in various tissues. CDTA, DTPA and tartaric acid are the most effective agents of those tested in the removal of strontium after a single administration.

References

Feb 1, 1977·Toxicology·R KroesG J van Esch
Jul 1, 1986·American Journal of Physical Anthropology·T D PriceE P Chase
Oct 1, 1986·Journal of Applied Toxicology : JAT·J L DomingoJ Corbella
Nov 26, 1971·Science·J L Omdahl, H F DeLuca

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Citations

Mar 1, 1990·Archives of Environmental Contamination and Toxicology·J M LlobetJ Corbella
Nov 1, 1991·Archives of Environmental Contamination and Toxicology·J M LlobetJ Corbella
Oct 8, 1998·Reproductive Toxicology·J L Domingo
Jul 1, 1995·Journal of Applied Toxicology : JAT·D J SánchezJ Corbella

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