The renal antihypertensive endocrine function: its relation to cytochrome P-450

Journal of Hypertension
E E MuirheadP S Brown

Abstract

Unclipping the Goldblatt hypertensive rat lowers the blood pressure by cells in the renal papilla, the renomedullary interstitial cells (RIC), secreting a hormone that is part of a vasodilator system. A vasodilator, termed medullipin I, can be extracted from the renal papilla. Medullipin I and the renal venous effluent following unclipping have identical biologic properties. Medullipin I appears to be the agent secreted by the kidney following unclipping. Both medullipin I and the renal venous effluent must traverse the liver to be active. Medullipin I is converted in the liver to its active form, medullipin II. The blood pressure-lowering effect of both medullipin I and the renal venous effluent after unclipping are blocked by SKF 525A, the inhibitor of cytochrome P-450. The relation of the kidney to the liver was tested using the rate of decline of the blood pressure after unclipping as an index of the endocrine antihypertensive function of the kidney--acceleration of the decline being considered as increased function, decrease of the decline as decreased function. Five compounds: BW755C, phenobarbital, ketoconazole, eicosatetraynoic acid (ETYA) and butylated hydroxytoluene (BHT), and two manipulations: uretero-caval anastomo...Continue Reading

Citations

Jun 1, 1991·Clinical and Experimental Pharmacology & Physiology·E E MuirheadJ A Pitcock
Feb 14, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bernhard Glodny, Guido F Pauli
Oct 1, 1992·Blood Pressure·E E MuirheadL W Byers
Sep 1, 1993·Blood Pressure·E E MuirheadE T Schroeder
Feb 1, 1992·The American Journal of the Medical Sciences·E E MuirheadL W Byers
Mar 1, 1991·Kidney International·K V Lemley, W Kriz
Jun 1, 1991·Hypertension·E E MuirheadL Share
Oct 23, 2002·Clinical and Experimental Pharmacology & Physiology·Christine MaricDaine Alcorn

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