The pivotal role of the kidney in sustaining hypertension from any source or etiology is becoming increasingly clear. The possibility that the renal vasculature participates not only in the pathogenesis of renal vascular hypertension, but also in that of essential hypertension, has been the subject of continuing interest for 40 years. Evidence that a functional abnormality resulting in increased renal vascular tone is present in about two-thirds of patients with uncomplicated essential hypertension is reviewed, along with more circumstantial evidence that sympathetic nervous system activity operating on the renal vasculature is responsible. Two additional groups of patients in whom a characteristic abnormality of the renal vasculature is present have also been identified. In one group there is severe hypertension which is resistant to most forms of antihypertensive therapy but which is especially responsive to propranolol. In these patients renal blood flow and glomerular filtration rate are reduced, renin secretion rate is increased and the renal vessels are resistant to vasodilators, suggesting the presence of advanced organic arteriolonephrosclerosis, as a complication of long-standing, severe hypertension. The renal lesion,...Continue Reading
Altered renal sodium handling and risk of incident hypertension: Results of the Olivetti Heart Study
Renal blood flow in pigs: changes depicted with contrast-enhanced harmonic US imaging during acute urinary obstruction
Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension
Acute combined alpha- and beta-adrenergic blockade in essential hypertension: effects on blood pressure, renal function, renin, and aldosterone
Abnormal renal haemodynamics during exercise in young patients with mild essential hypertension without treatment and during long-term propranolol therapy
Changes in renal function during the development of hypertension and effects of antihypertensive treatment. A case report
Relationships between sodium clearance, plasma renin activity, plasma aldosterone, renal hemodynamics and blood pressure in essential hypertension
Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction
Renal haemodynamic in essential hypertension assessed by 133-Xenon washout and selective renal angiography
Norepinephrine in urine and plasma following provocative maneuvers in normal and hypertensive subjects
The change of vascular reactivity to angiotensin II and norepinephrine in the two-kidney, one-clip renovascular hypertensive rabbit
Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension?
Urinary kallikrein activity, renal hemodynamics, and electrolyte handling during chronic beta blockade with propranolol in hypertension
Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion
G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension
Are renal hemodynamics a key factor in the development and maintenance of arterial hypertension in humans?
Effects of subpressor doses of angiotensin II on renal haemodynamics at different blood-pressure levels
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.