The renal clearance of amino acids in cystinuria

The Journal of Clinical Investigation
J C CRAWHALLR W WATTS

Abstract

The renal clearance of cystine, lysine, ornithine, arginine, and glycine has been compared with the simultaneously determined glomerular filtration rate in nine cystinuric patients. Five were studied before and after stabilization on penicillamine therapy, two were studied only while taking penicillamine, and two were studied only in the absence of penicillamine administration. The renal clearances of cysteine-penicillamine and of penicillamine disulfide were also determined in the patients who were taking the drug. Amino acids were determined by quantitative ion exchange chromatography, and the reliability of the method has been evaluated in terms of its reproducibility and of the recovery of known amounts of amino acids added to plasma and to urine. The plasma levels of cystine and of the basic amino acids were less than normal in all the patients. Cysteine-penicillamine and penicillamine disulfide were cleared by the kidney at rates similar to that of cystine. Two of the patients had glycine clearances that were considerably above the normal value. The renal clearance of cystine exceeded the glomerular filtration rate in six of the nine patients. The results form a continuum from values approximately equal to the glomerular ...Continue Reading

References

Dec 2, 1965·The New England Journal of Medicine·L E RosenbergJ M Holland
Mar 1, 1966·Annals of Human Genetics·J C CrawhallC J Thompson
Aug 1, 1955·Annals of Human Genetics·H HARRISF L WARREN
Dec 1, 1955·British Journal of Urology·C E DENT, B SENIOR
Sep 1, 1957·Nutrition Reviews
Aug 1, 1958·The Australian Journal of Experimental Biology and Medical Science·K D EDWARDS, H M WHYTE
Feb 1, 1962·The Journal of Clinical Investigation·G W FRIMPTERD D THOMPSON
Mar 2, 1963·British Medical Journal·J C CRAWHALLR W WATTS
Dec 1, 1963·The Journal of Clinical Investigation·G W FRIMPTER
Mar 12, 1964·The New England Journal of Medicine·M FOXS SEGAL
May 30, 1964·British Medical Journal·J C CRAWHALLR W WATTS
Mar 1, 1964·The Journal of Clinical Investigation·C R SCRIVERI A SCHAFER
Feb 13, 1965·British Medical Journal·C E DENTL C WATSON
May 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·G E SCHREINER

❮ Previous
Next ❯

Citations

Jan 1, 1974·Archiv Für Dermatologische Forschung·L H JansenJ B Van Der Meer
Jun 1, 1984·Pflügers Archiv : European journal of physiology·J A Schafer, M L Watkins
Mar 22, 1988·Biochimica Et Biophysica Acta·A ShimomuraD R Peterson
Jan 5, 1981·Life Sciences·A G Craan
Jan 1, 1989·Pharmacology & Therapeutics·D A Joyce
May 1, 1971·Comparative Biochemistry and Physiology. A, Comparative Physiology·K N Boorman
Jun 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·K N Boorman, I R Falconer
Apr 12, 1979·The New England Journal of Medicine·A E Broadus, S O Thier
Oct 1, 1969·Annals of Human Genetics·J C CrawhallE P Young
Dec 1, 1967·Archives of Disease in Childhood·D A GibbsR W Watts
Dec 1, 1968·Journal of Medical Genetics·S Kelly, W Copeland
Sep 1, 1971·The Journal of Clinical Investigation·C L MorinA Sass-Kortsak
Jul 1, 1974·The Journal of Clinical Investigation·O Simell, J Perheentupa
May 1, 1976·The Journal of Clinical Investigation·M BergeronC Schwab
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·R D Feld
Feb 1, 1976·Kidney International·C R ScriverR R McInnes
Jan 1, 1974·Metabolism: Clinical and Experimental·K C BoveeS Segal
Jul 1, 1984·Metabolism: Clinical and Experimental·K C Bovee, S Segal
Jan 1, 1980·Metabolism: Clinical and Experimental·J W ForemanS Segal
Aug 1, 1974·Metabolism: Clinical and Experimental·O Simell, J Perheentupa
Sep 1, 1977·The Journal of Pediatrics·S B MelançonM Potier
May 1, 1969·The American Journal of Medicine·G W Frimpter
Feb 23, 1999·The Urologic Clinics of North America·S P Dretler
Jan 1, 1978·American Journal of Medical Genetics·S Kelly
Dec 1, 1993·Biopharmaceutics & Drug Disposition·H Cheng, W J Jusko
Jan 16, 2008·Physiological Reviews·Stefan Bröer
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Esperanza FernándezJosep Chillarón
Dec 12, 2020·Journal of Clinical Medicine·Sofna BanjarnahorRenke Maas
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Esperanza FernándezManuel Palacín
Aug 25, 1982·Biochimica Et Biophysica Acta·S M HwangS Segal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.