The renal clearance of free and conjugated pyridinium cross-links of collagen

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A Colwell, R Eastell

Abstract

We developed a sensitive reversed-phase high performance liquid chromatography (HPLC) assay to measure free and total Pyridinoline (Pyr) and Deoxypyridinoline (Dpyr) in serum. The method was used to measure total serum levels in seven premenopausal women (ages 52.2 +/- 2.4 years) and to investigate the renal clearance of free and conjugated Pyr and Dpyr in two groups of children (group 1: 13 girls, ages 11-13 years; group 2: 18 older children [2 male, 16 female], ages 13-18 years). Blood and 24-h urine samples were collected from the younger group to measure the renal clearance, and blood and 2-h morning urine samples from the older group were collected to investigate the fractional clearance. Total Pyr and Dpyr in the premenopausal women was 4.08 +/- 0.91 and 1.18 +/- 0.39 nmol/l, respectively. Free and total Pyr and Dpyr in serum and urine was elevated in both groups of children. The free serum levels were 16 and 18% in young and older children, respectively, compared with 40 and 46% in the urine. The percentage of free Dpyr in serum decreased with total urinary Pyr excretion (r = -0.56, p < 0.005, n = 31). The renal clearance of the free cross-link fraction in both groups was 4-fold higher than the conjugated fraction. The f...Continue Reading

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Citations

Sep 3, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Edward A SchoberUlrich Schneider
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·P Garnero, P D Delmas
Nov 26, 1997·Annals of the Rheumatic Diseases·J H Tobias
Nov 13, 1998·Journal of Dairy Science·A LiesegangJ L Riond
Jan 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K E NaylorR Eastell
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P SzulcP D Delmas
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K E NaylorR Eastell
Jul 18, 2000·Cancer·A Fontana, P D Delmas
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y NishiB D Gelb
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jackie A ClowesRichard Eastell
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Jul 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Szulc, P D Delmas
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R HannonR Eastell
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Braga de Castro MachadoR Eastell
Mar 24, 1999·Pediatric Research·K E NaylorG L Klein
Jun 15, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SzulcP D Delmas
Sep 1, 2004·Annals of Hematology·Khalil Kargar SamaniXavier Leleu
Jun 3, 1999·Kidney International·P Ureña, M C De Vernejoul
Aug 1, 1997·Baillière's Clinical Rheumatology·P Garnero, P D Delmas
Jan 16, 1998·Endocrinology and Metabolism Clinics of North America·P Garnero, P D Delmas

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