PMID: 1171Jan 1, 1976

The renal elimination of procainamide

Clinical Pharmacology and Therapeutics
R L GaleazziL Z Benet

Abstract

The question of pH or flow dependence for the renal elimination of procainamide (PCA) was studied under 4 conditions in each of 4 subjects. Each subject received 500 mg of PCA intravenously at weekly intervals while in a state of (1) acid load (NH4Cl) and water deprivation, (2) acid load and water excess, (3) alkali load (NaHCO3) and water deprivation, and (4) alkali load and water excess. Plasma and urine were collected at frequent intervals for PCA and N-acetyl PCA (NAPA) analysis. Urine flow rates varied markedly between the water deprivation and water excess states (approximately 1.2 vs 5 ml/min, respectively), and urine pH varied markedly between the acid and alkali load states (pH = ca 5 vs 8, respectively). Despite this marked variation, there were no significant changes in PCA renal clearance or 24-hr PCA or NAPA excretion. If passive diffusion of PCA were taking place, such flow and pH changes would have caused marked changes in PCA clearance were the pH partition hypothesis true. We therefore conclude that passive diffusion is not an important mechanism in the renal elimination of PCA in man and that there must be tubular secretion. The implication for the clinical use of the drug is that dose adjustments need not be ...Continue Reading

Citations

Jun 18, 2002·Pediatric Emergency Care·Suzanne R WhiteJohn M Wilson
Jul 1, 1982·Pacing and Clinical Electrophysiology : PACE·T R Engel
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P B ChristoffW J Jusko
Jan 1, 1984·Annals of the New York Academy of Sciences·J T Bigger, E G Giardina
Mar 1, 1986·Pacing and Clinical Electrophysiology : PACE·P R Kowey, T D Friehling
May 1, 1991·Journal of Clinical Pharmacology·Y W LamK M Giacomini
Aug 1, 1984·British Journal of Clinical Pharmacology·A Somogyi, F Bochner
Jan 1, 1978·Acta Medica Scandinavica·I MattiassonB W Johansson
Feb 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·J J LimaW J Jusko

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