A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings.
Biocolloids of urine in health and in calculous disease. III. The mucoprotein matrix of urinary calculi
The renal lesions of electrolyte imbalance. I. The structural alterations in potassium-depleted rats
The effect of magnesium and fluoride on nephrocalcinosis and aortic calcification in rats given high sucrose diets with added phospnates
The influence of the parathyroid glands on the hypercalcemia of experimental magnesium depletion in the rat
Nephrolithiasis in free-ranging North American river otter (Lontra canadensis) in North Carolina, USA
Isolation and partial characterization of kidney stone matrix induced by magnesium deficiency in the rat
Distribution of calcium and magnesium in rat kidney homogenate fractions accompanying magnesium deficiency induced nephrocalcinosis
Effects of magnesium deficiency on intratubular calcium oxalate formation and crystalluria in hyperoxaluric rats
The evaluation of urinary protein patterns in a stone-forming animal model using two-dimensional polyacrylamide gel electrophoresis
Calcium and oxalate concentrations in human renal tissue: the key to the pathogenesis of stone formation?
Nephrocalcinosis as a source for renal stone nuclei. Observations on humans and squirrel monkeys and on hyperparathyroidism in the squirrel monkey
Bladder Carcinoma In Situ
Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.