PMID: 5919693Aug 1, 1966

The renal lesions of electrolyte imbalance. IV. The intranephronic calculosis of experimental magnesium depletion

The Journal of Experimental Medicine
J R OliverL G Welt

Abstract

A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings.

References

Oct 1, 1956·The Journal of Clinical Investigation·W H Boyce, N M SULKIN
Oct 1, 1957·The Journal of Experimental Medicine·J R OliverW E SEGAR
Mar 1, 1963·The Journal of Clinical Investigation·R Whang, L G Welt
Jul 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·L K DAHL

Citations

Jan 1, 1997·World Journal of Urology·S R Khan
Aug 28, 2009·Urological Research·Y M Fazil MarickarPeter Koshy
Aug 15, 1969·Annals of the New York Academy of Sciences·R WhangM MacDowell
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Apr 10, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jennifer N NiemuthMichael K Stoskopf
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Sep 1, 1994·Kidney International·D J Kok, S R Khan
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Sep 23, 2018·Scientific Reports·Sunita P HoMarshall L Stoller

Related Concepts

Magnesium Deficiency
Nephrocalcinosis
Water-Electrolyte Balance

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