The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice

Pflügers Archiv : European journal of physiology
Manuel MeurerKlaus Höcherl

Abstract

Endotoxemia-related acute kidney injury (AKI) is associated with increased formation of prostaglandins, which may serve as a compensatory mechanism to maintain renal function. We hypothesized that an increase of renal EP2 or EP4 receptors and/or a downregulation of renal EP1 and EP3 receptors enhances PGE2-induced renal vasodilatation. Injection of lipopolysaccharide (LPS; 3 mg/kg i.p.) increased microsomal prostaglandin E synthase (mPGES)-1 and prostacyclin synthase expression, whereas mPGES-2 expression was unaltered. Further, LPS increased the mRNA abundance for the prostaglandin EP4 receptor, whereas the expressions of the EP1 and EP3 receptors were decreased. In isolated-perfused kidneys from control mice, PGE2 exerted a dual effect on renal vascular tone, inducing vasodilatation at lower concentrations and vasoconstriction at higher concentrations. In kidneys from endotoxemic mice, the vasodilatory component was more pronounced, whereas the vasoconstriction at higher PGE2 concentrations was absent. Similarly, prostacyclin (PGI2)-induced vasodilatation was more pronounced in endotoxemic kidneys. The enhanced vasodilatory effect was paralleled by an increase in renal vascular EP4 and prostacyclin IP receptor mRNA expression...Continue Reading

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Citations

Feb 7, 2019·Pflügers Archiv : European journal of physiology·Manuel Meurer, Klaus Höcherl
Jun 28, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Lena R Thurner, Klaus Höcherl
Jan 28, 2019·Pflügers Archiv : European journal of physiology·Manuel Meurer, Klaus Höcherl
Oct 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin LiuYingbi Zhou
Jan 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Le NingYinchuan Xu

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PCR

Software Mentioned

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GraphPad Prism

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