PMID: 7008062Dec 1, 1980Paper

The renin--kallikrein--prostaglandin system: plasma active and inactive renin and urinary kallikrein during prostacyclin infusion in man

Prostaglandins and Medicine
G A FitzGeraldA Konrads

Abstract

Renal prostaglandins are integrated with the kallikrein-kinin and renin-angiotension systems in a vasoactive hormone complex. Prostacyclin potently stimulates renin release from rabbit cortical slices and plasma renin activity rises in response to prostacyclin infusion in man. Prostaglandins also stimulate the production of kallikrein, a potential activator of renin in vivo. To investigate the mechanism of prostacyclin induced renin release, human volunteers were infused with prostacyclin 8ngKg-1min-1 and vehicle alone in random order. Despite a marked increase in plasma active renin during prostacyclin both plasma inactive renin and urinary kallikrein failed to alter from control values. Urinary sodium and volume were increased by prostacyclin. The stimulation of renin by intravenous prostacyclin is not mediated by activation of the kallikrein system.

References

Jul 1, 1978·Clinical Science and Molecular Medicine·A A ShulkesS L Skinner
May 3, 1979·Klinische Wochenschrift·W HummerichG Wambach
Jun 7, 1979·The New England Journal of Medicine·O K ole-MoiYoiK F Austen
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·E E Slater, E Haber
Feb 1, 1979·Clinical Science·F H DerkxM A Schalekamp
Jun 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R H NothJ Havelick

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Citations

May 1, 1985·Prostaglandins, Leukotrienes, and Medicine·R T MasonB A Scoggins
Apr 17, 1986·The New England Journal of Medicine·J L NadlerR Horton
Jul 12, 2011·Critical Care Clinics·Nitin Puri, Richard Phillip Dellinger
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Jan 1, 1985·CRC Critical Reviews in Toxicology·P H Bach, J W Bridges
Jun 1, 1986·European Journal of Clinical Investigation·A PierucciF Pugliese
Jan 1, 1985·Medicinal Research Reviews·R C NickolsonH Vorbrüggen
Aug 1, 1982·British Journal of Clinical Pharmacology·H Pickles, J O'Grady

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