The renin-aldosterone axis in two models of reduced renal mass in the rat.

Journal of the American Society of Nephrology : JASN
H N Ibrahim, T H Hostetter

Abstract

The renin-angiotensin-aldosterone system participates in chronic progressive renal disease. The studies presented here assessed the importance of aldosterone in two different methods of reduced kidney mass in the rat, i.e., the infarction model (INF; uninephrectomy plus infarction of approximately two-thirds of the other kidney) and surgical excision or polectomy (POL; uninephrectomy plus surgical excision of both poles of the other kidney). Equivalent degrees of reduction in renal mass were confirmed by the similarity of serum creatinines 3 d after the ablative procedure. Measurements were made thereafter at 2 and 4 wk postablation. Systolic arterial pressure was greater with INF at both 2 and 4 wk. Proteinuria was also greater in the INF group at both time periods. The percentage of glomeruli with sclerosis measured at 4 wk tended to be greater in the INF group; however, this difference was not of statistical significance. At 2 wk, plasma renin activity and plasma aldosterone levels were lower in the POL group. The renin concentration in the scar region of the kidneys in the INF group was higher than in the kidney of the POL group. In conjunction with the lower plasma aldosterone, rats in the POL group had higher plasma potas...Continue Reading

Citations

Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E BrochuR Larivière
Jun 10, 2000·Current Opinion in Nephrology and Hypertension·A B Fogo
Feb 24, 2001·Current Opinion in Nephrology and Hypertension·T H HostetterI Juknevicius
Jul 20, 1999·Kidney International·S Kren, T H Hostetter
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Karen A GriffinAnil K Bidani
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Hassan N Ibrahim, Thomas H Hostetter
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Masaomi NangakuWilliam G Couser
Jun 6, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shuzo KobayashiTaneo Fukuda
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·Hassan N Ibrahim, Thomas H Hostetter
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Jun 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hye Won ParkMichael Mauer

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