The renin-angiotensin-aldosterone system and its suppression

Journal of Veterinary Internal Medicine
Marisa K AmesBertram Pitt

Abstract

Chronic activation of the renin-angiotensin-aldosterone system (RAAS) promotes and perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic kidney disease. Excessive circulating and tissue angiotensin II (AngII) and aldosterone levels lead to a pro-fibrotic, -inflammatory, and -hypertrophic milieu that causes remodeling and dysfunction in cardiovascular and renal tissues. Understanding of the role of the RAAS in this abnormal pathologic remodeling has grown over the past few decades and numerous medical therapies aimed at suppressing the RAAS have been developed. Despite this, morbidity from these diseases remains high. Continued investigation into the complexities of the RAAS should help clinicians modulate (suppress or enhance) components of this system and improve quality of life and survival. This review focuses on updates in our understanding of the RAAS and the pathophysiology of AngII and aldosterone excess, reviewing what is known about its suppression in cardiovascular and renal diseases, especially in the cat and dog.

Associated Clinical Trials

References

Oct 1, 1977·Annals of Internal Medicine·L I RoseG H Williams
Sep 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M PragaJ L Rodicio
Mar 1, 1992·Hypertension·W WangI H Zucker
Dec 1, 1990·Circulation Research·C G BrillaK T Weber
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Dec 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T KawasakiK Shinkawa
Apr 1, 1990·Circulation Research·H UrataA Husain
Dec 1, 1989·European Heart Journal·M BroqvistT Marklund
Jan 1, 1987·British Heart Journal·J BaylissP Poole-Wilson
Dec 1, 1972·Annals of Biomedical Engineering·A C GuytonR D Manning
Oct 14, 1971·The New England Journal of Medicine·D L EckbergE Braunwald
Jul 1, 1972·Journal of Pharmaceutical Sciences·W SadéeS C Jones
Aug 1, 1981·Maturitas·P CuginiF Massimiani
Dec 1, 1981·The Journal of Endocrinology·J StaessenA Amery
Mar 1, 1980·The Journal of Endocrinology·J LevyS M Glick
Nov 2, 1995·The American Journal of Cardiology·C G BrillaK T Weber
Apr 1, 1993·The Journal of Clinical Investigation·H UrataA Husain
Feb 1, 1995·Hypertension·Y TakedaR Takeda
Jun 1, 1994·The Journal of Clinical Investigation·M YoungJ Funder
Jun 1, 1993·The American Journal of Physiology·M E UllianT A Morinelli

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Citations

Nov 16, 2019·Journal of Veterinary Internal Medicine·Yumi SakamotoToshihiro Watari
Jun 6, 2020·Anesthesiology·Gladness Dakalo NethatheCharles Feldman
May 10, 2020·Molecular Psychiatry·Charlotte SteenblockStefan R Bornstein
Apr 2, 2020·Frontiers in Physiology·Bianca Domingues MassoliniOvidiu Constantin Baltatu
Mar 5, 2020·Journal of Veterinary Pharmacology and Therapeutics·Sarah SpencerJonathan Elliott
Aug 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaolu ZhangShouzhu Xu
Jul 12, 2020·Current Gastroenterology Reports·Ki Tae YoonSamuel S Lee
Aug 9, 2020·Drug Design, Development and Therapy·Tavga Ahmed AzizZheen Aorahman Ahmed
Sep 22, 2019·International Journal of Molecular Sciences·Ineke BöckmannMaren Leifheit-Nestler
Jun 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yonas Akalu, Yitayeh Belsti
Nov 4, 2020·Journal of Magnetic Resonance Imaging : JMRI·Anneloes de BoerAnna Caroli
Nov 12, 2020·International Journal of Molecular Sciences·Ivona KosovicMirna Saraga-Babic
Nov 23, 2020·International Immunopharmacology·Rasoul MirzaeiSajad Karampoor
Feb 3, 2021·Hipertensión y riesgo vascular·M Molina-Van den BoschM J Soler
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Qi LiuJunjie Xiao
Dec 31, 2020·Anesthesiology·Gladness Dakalo NethatheCharles Feldman
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Richard A Stein, Lauren M Young
Dec 6, 2020·Journal of Cardiovascular Pharmacology·Christopher S Wilcox, Bertram Pitt
Mar 31, 2021·Molecular and Cellular Endocrinology·Fitra RiantoMatthew A Sparks
May 1, 2021·International Journal of Molecular Sciences·Yoshimichi TakedaYoshiyu Takeda
May 21, 2021·The Tohoku Journal of Experimental Medicine·Xin GaoHironobu Sasano
Jul 15, 2021·Canine Medicine and Genetics·D B AdinK M Meurs
Jul 13, 2021·The Veterinary Journal·Sarah SpencerJonathan Elliott
Jul 8, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fangfang LiQing Li
Jul 29, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·A LaskaryM L O'Sullivan
Aug 8, 2021·Cells·Beatriz Delgado-ValeroErnesto Martínez-Martínez
Aug 26, 2021·Journal of Feline Medicine and Surgery·Jack S Lawson, Rosanne E Jepson
Aug 29, 2021·Pharmaceutics·Nolwenn TessierCatherine Martel
Sep 3, 2021·Journal of Veterinary Internal Medicine·Cailin C HarroDaniel K Langlois
Sep 1, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·José Silva-CardosoDulce Brito
May 31, 2021·European Journal of Nutrition·Roya Kolahdouz-MohammadiAmin Salehi-Abargouei

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Methods Mentioned

BETA
transgenic
pharmacotherapy

Clinical Trials Mentioned

NCT02901184
NCT02545049
NCT02540993

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