The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion

International Journal of Endocrinology
Simón Quetzalcóatl Rodríguez-LaraAlejandra Guillermina Miranda-Díaz

Abstract

Ischemia-reperfusion (I/R) injury is a well-known phenomenon that involves different pathophysiological processes. Connection in diverse systems of survival brings about cellular dysfunction or even apoptosis. One of the survival systems of the cells, to the assault caused by ischemia, is the activation of the renin-angiotensin-aldosterone system (also known as an axis), which is focused on activating diverse signaling pathways to favor adaptation to the decrease in metabolic supports caused by the hypoxia. In trying to adapt to the I/R event, great changes occur that unchain cellular dysfunction with the capacity to lead to cell death, which translates into a poor prognosis due to the progression of dysfunction of the cellular activity. The search for the understanding of the diverse therapeutic alternatives in molecular coupling could favor the prognosis and evolution of patients who are subject to the I/R process.

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Feb 18, 1977·Brain Research·N E SirettJ I Hubbard
Jan 1, 1992·Annual Review of Physiology·K M BakerD E Dostal
Oct 1, 1988·Trends in Neurosciences·M P Blaustein
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J K DeshpandeT Wieloch
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P M HobartJ M Chirgwin
Oct 1, 1984·Journal of Neurochemistry·G A Dienel
Jul 1, 1982·Journal of Neuropathology and Experimental Neurology·C K PetitoF Plum
Mar 1, 1981·Stroke; a Journal of Cerebral Circulation·E Siemkowicz, A J Hansen
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R J HarrisM Bayhan
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Sep 1, 1996·The American Journal of Physiology·J PetersE Hackenthal
May 3, 2000·Kidney International·M W Taal, B M Brenner
Oct 18, 2000·Free Radical Biology & Medicine·E Cadenas, K J Davies
Sep 26, 2001·Circulation·T Münzel, J F Keaney
Nov 24, 2001·Trends in Cell Biology·S H Kaufmann, M O Hengartner
Dec 12, 2001·Kidney International·J P van KatsA H Danser
May 23, 2002·Hypertension·Herbert L JackmanErvin G Erdös
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sergey V BrodskyMichael S Goligorsky
Jan 16, 2003·American Journal of Physiology. Renal Physiology·Madhu BhaskaranPravin C Singhal
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Rekha SinghDavid J Leehey
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena M V de CavanaghCesar G Fraga
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Dec 25, 2003·Diabetes Care·Mark E MolitchUNKNOWN American Diabetes Association
Aug 20, 2004·The Journal of Biological Chemistry·Florian L MullerHolly Van Remmen
Sep 3, 2004·Nature·Daniel J Klionsky
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Nov 10, 2004·Molecular and Cellular Biochemistry·Michael J Goldenthal, José Marín-García
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Christoph J WruckThomas Unger
Mar 2, 2005·Nature Reviews. Cancer·J Martin Brown, Laura D Attardi
Apr 2, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Walmor C De Mello
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·A Yu AndreyevA A Starkov
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Nancy J Brown
Sep 1, 2005·Circulation·Jackie BoschUNKNOWN HOPE/HOPE-TOO Study Investigators
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lin YanStephen F Vatner
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed

❮ Previous
Next ❯

Citations

Mar 12, 2019·Canadian Journal of Physiology and Pharmacology·Kamal M KassemNour-Eddine Rhaleb
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Simón Quetzalcoatl Rodríguez-LaraLeonel García-Benavides
Aug 18, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Azza S AwadRehab Kamel

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung
W Oelkers
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
J H Vogt
Deutsche medizinische Wochenschrift
W Gramann
© 2022 Meta ULC. All rights reserved