PMID: 6106579May 1, 1980Paper

The renin-angiotensin-aldosterone system, antidiuretic hormone levels and water balance under tocolytic therapy with Fenoterol and Verapamil

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
G GrospietschW Kuhn

Abstract

The effects of long-term infusion of fenoterol (a beta 2-sympathomimetic drug) in combination with the calcium antagonist verapamil on water balance, the renin-angiotensin-aldosterone system and antidiuretic hormone during pregnancy were studied. Within two hours of the start of infusion, plasma renin and antidiuretic hormone levels were significantly increased, but plasma aldosterone was strongly decreased. There was a concomitant marked reduction of urinary, sodium, and potassium excretion and a decreased creatinine clearance. The long-lasting reduction of urinary excretion which resulted in an elevated water retention is apparently due to other unknown factors. Results are discussed with special regard to the relationship between water balance disturbances and pulmonary edema.

References

Mar 1, 1977·American Journal of Obstetrics and Gynecology·R Richter
Sep 1, 1977·American Journal of Obstetrics and Gynecology·J Lipshitz
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·T HimathongkamG H Williams
Mar 1, 1971·Endocrinology·J E BoydP J Mulrow
Aug 1, 1969·Endocrinology·J W FunderR D Wright

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Citations

Mar 1, 1994·Anaesthesia·S J Rodgers, M Morgan
Apr 12, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·R F Lamont
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·D W Boulton, J P Fawcett
Oct 27, 2004·Expert Opinion on Drug Safety·Peter G PrydeRobert Mittendorf
Feb 11, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ali KamiarLina A Shehadeh
Nov 1, 1983·The Journal of Pediatrics·N B HansenB S Stonestreet

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