The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker

Circulation
M RuzickaF H Leenen

Abstract

The degree of cardiac hypertrophy is not only load dependent: Among other factors, the renin-angiotensin system may play a role in the regulation of cardiac myocyte growth. To evaluate the role of the renin-angiotensin system in volume overload-induced cardiac hypertrophy, we assessed: 1) the time course of changes in cardiac hemodynamics, cardiac anatomy, and plasma and cardiac renin activity in response to volume overload induced by two sizes of abdominal aortocaval shunt and 2) the effects of chronic treatment with an angiotensin converting enzyme inhibitor (ACEI) versus an angiotensin II receptor blocker on hemodynamics and cardiac hypertrophy. Drug treatment started 3 days before shunt surgery. An increase in left ventricular end-diastolic pressure (LVEDP) and the development of right ventricular (RV) and left ventricular (LV) eccentric hypertrophy in response to volume overload occurred within the first week after induction of the shunt. Plasma renin activity (PRA) and cardiac renin activity peaked shortly after induction of the shunt. During the chronic phase, LVEDP and PRA decreased somewhat but remained significantly elevated up to 7 weeks after shunt surgery. Cardiac renin activity returned toward normal within 4 week...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Jun 1, 1976·The Journal of Clinical Investigation·L WatkinsA C Barger
Aug 1, 1975·The American Journal of Physiology·R H FreemanT E Lohmeier
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·R D SmithP B Timmermans
May 1, 1990·Cardiovascular Research·R Garcia, S Diebold
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·W LinzD Ganten
Apr 1, 1989·American Journal of Hypertension·W LinzD Ganten
Jun 1, 1988·The Journal of Clinical Investigation·S IsoyamaJ Y Wei
Aug 1, 1988·The Biochemical Journal·N J SamaniW J Brammar
Sep 1, 1983·Hypertension·M LoudonJ D Swales
Jun 1, 1980·Pflügers Archiv : European journal of physiology·S F FlaimR Zelis
Jun 1, 1953·The Journal of Clinical Investigation·F H EPSTEINM E MCDOWELL
Jul 1, 1949·The American Journal of Physiology·A VAN LOO, E C HERINGMAN

❮ Previous
Next ❯

Citations

Jun 1, 1995·Clinical Cardiology·C J Kaupke
Jun 27, 1994·FEBS Letters·A W HahnT J Resink
Jul 1, 1994·Trends in Pharmacological Sciences·R Schulz, C R Triggle
Oct 1, 1994·Journal of the American College of Cardiology·M LinM D Cheitlin
Oct 15, 1993·European Journal of Pharmacology·C DeliséeP Chatelain
Dec 31, 1997·The American Journal of Cardiology·J N Cohn
Apr 6, 2000·The American Journal of Cardiology·B H Lorell
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Hironori NakagamiJames K Liao
Jul 9, 1999·Progress in Lipid Research·J C DeMarR E Anderson
Mar 1, 2002·Journal of the American College of Cardiology·Nathalie Lapointe, Jean Lucien Rouleau
Jan 1, 1997·Cellular Signalling·J A Boutin
Aug 1, 1996·Trends in Cardiovascular Medicine·P DelafontaineJ Du
Apr 1, 1996·Clinical and Experimental Pharmacology & Physiology·J ZhuoF A Mendelsohn
Feb 28, 2007·Clinical and Experimental Pharmacology & Physiology·Micheline M de Resende, José G Mill
Nov 1, 1996·Heart·T Morgan, H R Brunner
Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Nov 30, 1999·Anesthesia and Analgesia·P ColsonP Coriat
Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Trefor Morgan
Dec 17, 1998·The Journal of Endocrinology·H KoboriT Saruta
Mar 4, 2008·American Journal of Veterinary Research·Masami UechiShigeki Yamano
Nov 5, 2002·European Journal of Heart Failure·GianCarlo MarenziPiergiuseppe Agostoni
Dec 18, 2001·General and Comparative Endocrinology·W G AndersonN Hazon
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Zaid AbassiAaron Hoffman
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Xiaobing GuoNaranjan S Dhalla
Oct 10, 1997·Journal of Hypertension·N OhmichiM Kinoshita
Dec 1, 1993·Journal of Cellular Biochemistry·G MünsI Rubinstein
Nov 26, 2011·Kidney & Blood Pressure Research·Vojtech MelenovskyLudek Cervenka
Aug 22, 2006·European Journal of Heart Failure·Laercio Martins De StefanoBeatriz Bojikian Matsubara

❮ Previous
Next ❯

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